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Anti-S100 beta antibody [SH-B1] (ab11178)

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Overview

Product name

Anti-S100 beta antibody [SH-B1]
See all S100 beta products (13) ...

Description

Mouse monoclonal [SH-B1] to S100 beta

Specificity

The product does not react with other members of the EF-hand family such as calmodulin, parvalbumin, intestinal calcium binding protein, and myosin light chain. The antibody should recognise S100a and S100b but not S100ao.

Tested applications

WB, ELISA, IHC-P, Dot Blot, ICC/IFmore details

Cross reactivity

Reacts with

Rat, Rabbit, Cow, Cat, Human, Pig

Immunogen

Full length native protein (purified) (Cow).

Positive control

Human tongue tissue slide (IHC-P).

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide

Concentration

Concentration information loading...

Purity

Ascites

Clonality

Monoclonal

Clone number

SH-B1

Isotype

IgG1

Research areas

Stem Cells >> Neural Stem Cells >> Glial Restricted Lineage >> Astrocyte
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Cell Biology >> Cell Cycle >> Cell differentiation

Applications

Show applications key

Our Abpromise guarantee covers the use of ab11178 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Tissue specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Sequence similarities

Belongs to the S-101 family.
Contains 2 EF-hand domains.

Cellular localization

Cytoplasm. Nucleus.

Target information above from: UniProt accessionP04271 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • NEF antibody
  • Protein S100 B antibody
  • Protein S100-B antibody
  • S 100 calcium binding protein beta chain antibody
  • S 100 protein beta chain antibody
  • S 100 protein beta subunit antibody
  • S-100 protein beta chain antibody
  • S-100 protein subunit beta antibody
  • S100 antibody
  • S100 calcium binding protein B antibody
  • S100 calcium binding protein beta (neural) antibody
  • S100 calcium binding protein beta chain antibody
  • S100 calcium-binding protein B antibody
  • S100 protein beta chain antibody
  • S100B antibody
  • S100B_HUMAN antibody
  • S100beta antibody
see all

Database links

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References for Anti-S100 beta antibody [SH-B1] (ab11178)

This product has been referenced in:

  • D'Aldebert Eet al. Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice. Gastroenterology 140:275-85 (2011). IHC-P; Human.Read more (PubMed: 20888819) »
  • Furrer SAet al. Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration. J Neurosci 31:16269-78 (2011).Read more (PubMed: 22072678) »

See all 6 publications for this product

Publishing research using ab11178? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"