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Products:Cell Biology >> Cell Cycle >> Cell differentiation
Overview
Product name
Anti-S100 beta antibody
See all S100 beta products (13) ...
Description
Rabbit polyclonal to S100 beta
Specificity
Does not cross react with other calcium binding proteins including calbindin, calretinin or parvalbumins.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Full length native protein homodimer (purified) (Human) (Peptide available as ab30380.)
Positive control
Rat brain tissue lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Neural Stem Cells >> Glial Restricted Lineage >> Astrocyte
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Cell Biology >> Cell Cycle >> Cell differentiation
Applications
Show applications key
Our Abpromise guarantee covers the use of ab14688 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP
IP: 1/250IP: 1/250
Application notes
Is unsuitable for or IHC-Fr.
Target
Function
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Tissue specificity
Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
Sequence similarities
Belongs to the S-101 family.
Contains 2 EF-hand domains.
Cellular localization
Cytoplasm. Nucleus.
Target information above from: UniProt accessionP04271
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- NEF antibody
- Protein S100 B antibody
- Protein S100-B antibody
see all
Database links
- Entrez Gene: 6285 Human
- Entrez Gene: 20203 Mouse
- Entrez Gene: 25742 Rat
- Omim: 176990 Human
- SwissProt: P04271 Human
- SwissProt: P50114 Mouse
- SwissProt: P04631 Rat
- Unigene: 422181 Human
see all
References for Anti-S100 beta antibody (ab14688)
This product has been referenced in:
- Colin Aet al. Engineered lentiviral vector targeting astrocytes in vivo. Glia 57:667-79 (2009).Read more (PubMed: 18942755) »
- Harrison SJet al. Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb. Cereb Cortex : (2007).Read more (PubMed: 18024993) »
See all 3 publications for this product
Publishing research using ab14688? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"