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Products:Cell Biology >> Cell Cycle >> Cell differentiation
Overview
Product name
S100 beta protein
See all S100 beta products (5) ...
Protein description
Recombinant full length protein, corresponding to amino acids 1-92 of Human S100 beta
Expression host
E. coli
Properties
Purity
>95% by SDS-PAGE
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50mM Potassium chloride, 30mM HEPES, pH 6.5
Note: Under these conditions, to avoid precipitation, the product can be concentrated to a maximum of 0.2mM (dimer).
Concentration
Concentration information loading...
Research areas
Stem Cells >> Neural Stem Cells >> Glial Restricted Lineage >> Astrocyte
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Cell Biology >> Cell Cycle >> Cell differentiation
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54050 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution. (This protein runs as a monomer giving a single band migrating at a molecular weight of <14 kDa. )
Protein info
Function
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Tissue specificity
Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
Sequence similarities
Belongs to the S-101 family.
Contains 2 EF-hand domains.
Cellular localization
Cytoplasm. Nucleus.
Target information above from: UniProt accessionP04271
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for S100 beta protein (ab54050)
This product has been referenced in:
- Degerman Gunnarsson Met al. Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study. Dement Geriatr Cogn Disord 29:204-12 (2010).Read more (PubMed: 20332638) »
- Esposito Get al. Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury. Hum Mol Genet 17:440-57 (2008).Read more (PubMed: 17984171) »
See all 2 publications for this product
Publishing research using ab54050? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"