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Anti-S100A12 antibody [19F5] (ab50250)

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Overview

Product name

Anti-S100A12 antibody [19F5]
See all S100A12 products (3) ...

Description

Mouse monoclonal [19F5] to S100A12

Specificity

This antibody reacts specifically with the 10kDa human S100A12 protein. In WB the antibody show no cross reactivity with the following S100 protein family: A7, A8, A9 and A10. Other members of this S100 protein family have not been tested.

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein (Human)

Positive control

Recombinant protein and on human neutrophils lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Ascites

Concentration

Concentration information loading...

Purity

Ascites

Clonality

Monoclonal

Clone number

19F5

Isotype

IgG1

Light chain type

kappa

Research areas

Immunology >> Secreted Molecules >> Other secreted molecules
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Binding Proteins
Immunology >> Innate Immunity >> Cytokines >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab50250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. Plays an important role in the inflammatory response. Interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.

Tissue specificity

Monocytes and lymphocytes.

Sequence similarities

Belongs to the S-101 family.
Contains 2 EF-hand domains.

Target information above from: UniProt accessionP80511 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CAAF1 antibody
  • CAGC antibody
  • Calcitermin antibody
  • Calcium binding protein in amniotic fluid antibody
  • Calcium-binding protein in amniotic fluid 1 antibody
  • Calgranulin C antibody
  • Calgranulin related protein antibody
  • Calgranulin-C antibody
  • CGRP antibody
  • EN RAGE antibody
  • EN-RAGE antibody
  • ENRAGE antibody
  • Extracellular newly identified RAGE binding protein antibody
  • Extracellular newly identified RAGE-binding protein antibody
  • MRP6 antibody
  • Neutrophil S100 protein antibody
  • p6 antibody
  • Protein S100 A12 antibody
  • S100 calcium binding protein A12 antibody
  • S100 calcium-binding protein A12 antibody
  • S100A12 antibody
  • S10AC_HUMAN antibody
see all

Database links

References for Anti-S100A12 antibody [19F5] (ab50250)

ab50250 has not yet been referenced specifically in any publications.

Publishing research using ab50250? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"