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Product Name
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S100A12 antibody [19F5]
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See all S100A12 antibodies (2)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [19F5] to S100A12
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Immunogen
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Recombinant full length protein (Human)
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Reacts with
(species key)
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Hu
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Specificity
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This antibody reacts specifically with the 10kDa human S100A12
protein. It shows no cross reactivity with the other S100 protein family.
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: 1/200 - 1/1000. Predicted molecular weight: 10 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Recombinant protein and on human neutrophils lysate.
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Cellular localization
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Secreted
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Research areas
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Immunology >> Secreted Molecules >> Other secreted molecules
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Binding Proteins
Immunology >> Innate Immunity >> Cytokines >> Other
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Relevance
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S100 family proteins are acidic low molecular weight proteins containing 2 EF-hand calcium binding domains. They are characterised by their cell-type specific expression patterns. S100A12 is a member of the calgranulin sub-family. Calgranulins are S100 proteins that are expressed by neutrophils and also found in infiltrating monocytes and granulocytes during chronic inflammation. S100A12 is expressed in neutrophils and monocytes. It is highly abundant in resting neutrophils, comprising 5% of total cytostolic protein.
S100A12 is a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE.
S100A12 has also been shown to have anti-microbial properties.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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19F5
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Ascites
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Storage buffer
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Preservative: None
Constituents: Ascites
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this S100A12 antibody [19F5] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to S100A12
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S100A12 antibody [19F5] - more information
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