Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Immunology >> Innate Immunity >> Cytokines >> Other
Overview
Product name
Anti-S100A12 antibody
See all S100A12 products (3) ...
Description
Rabbit polyclonal to S100A12
Tested applications
IHC-Fr, WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant S100A12 (Human) with 6x His tag
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Secreted Molecules >> Other secreted molecules
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Binding Proteins
Immunology >> Innate Immunity >> Cytokines >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37657 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: 1/2000
WB: 1/1000 - 1/10000.Detects a band of approximately 10.5 kDa (predicted molecular weight: 10.5 kDa).
ELISA
ELISA: 1/2000 - 1/10000.ELISA: 1/2000 - 1/10000.
Target
Function
Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. Plays an important role in the inflammatory response. Interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators.
Tissue specificity
Monocytes and lymphocytes.
Sequence similarities
Belongs to the S-101 family.
Contains 2 EF-hand domains.
Target information above from: UniProt accessionP80511
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CAAF1 antibody
- CAGC antibody
- Calcitermin antibody
see all
Database links
- Entrez Gene: 6283 Human
- Omim: 603112 Human
- SwissProt: P80511 Human
- Unigene: 19413 Human
Anti-S100A12 antibody images:
Western blot - S100A12 antibody (ab37657)
Anti-S100A12 antibody (ab37657) + 200 ng recombinant human S100A12
Secondary
anti-rabbit IgG alkalind phosphatase conjugate
Predicted band size : 10.5 kDa
Observed band size : 10.5 kDa
Additional bands at : 21 kDa (possible dimer).
Immunohistochemistry (Frozen sections) - S100A12 antibody (ab37657)
Anti-S100A12 antibody (ab37657) detects macrophage infiltrates expressing S100A12 in colon tissues from a patient with Crohn’s disease.
References for Anti-S100A12 antibody (ab37657)
This product has been referenced in:
- Srikrishna Get al. Carboxylated glycans mediate colitis through activation of NF-kappa B. J Immunol 175:5412-22 (2005).Read more (PubMed: 16210648) »
- Gawdzik Jet al. Vascular remodeling and arterial calcification are directly mediated by S100A12 (EN-RAGE) in chronic kidney disease. Am J Nephrol 33:250-9 (2011).Read more (PubMed: 21372560) »
See all 5 publications for this product
Publishing research using ab37657? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"