Anti-S1P antibody - C-terminal (ab224618)
Key features and details
- Rabbit polyclonal to S1P - C-terminal
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-S1P antibody - C-terminal
See all S1P primary antibodies -
Description
Rabbit polyclonal to S1P - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat, Chinese hamster -
Immunogen
Recombinant fragment corresponding to Human S1P aa 800 to the C-terminus (C terminal).
Database link: Q14703 -
Positive control
- IHC-P: Human lung and small intestine tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab224618 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
Use at an assay dependent concentration.
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IHC-P |
1/20 - 1/200.
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Notes |
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WB
Use at an assay dependent concentration. |
IHC-P
1/20 - 1/200. |
Target
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Relevance
S1P (also known as MBTPS1,SKI1), was first discovered as one of two enzymes that cleave the sterol regulatory binding proteins (SREBPs), in the case of S1P at “site-1,” a hydrophillic loop extending into the lumen of the ER. The MBTPS1 domain structure contains a signal sequence followed by a propeptide domain, a catalytic domain, a transmembrane domain and a cytoplasmic domain. -
Cellular localization
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. -
Database links
- Entrez Gene: 100689417 Chinese hamster
- Entrez Gene: 8720 Human
- Entrez Gene: 56453 Mouse
- Entrez Gene: 89842 Rat
- Omim: 603355 Human
- SwissProt: Q9Z2A8 Chinese hamster
- SwissProt: Q14703 Human
- SwissProt: Q9WTZ2 Mouse
see all -
Alternative names
- kexin isozyme 1 antibody
- KIAA0091 antibody
- MBTPS1 antibody
see all
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab224618 has been referenced in 1 publication.
- Wu X et al. Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction. Comput Math Methods Med 2022:5985375 (2022). PubMed: 35872958