Overview

  • Product nameAnti-SAE1 antibody
    See all SAE1 primary antibodies
  • Description
    Rabbit polyclonal to SAE1
  • Tested applicationsELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, derived from within residues 10-30 at the C terminal of the last 50 amino acids of AOS1 (Human).

  • Positive control
    • Mouse heart tissue lysate (WB). Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab38434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 38 kDa.
IHC-P 1/50 - 1/100.

Target

  • FunctionThe heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
  • Tissue specificityExpression level increases during S phase and drops in G2 phase (at protein level).
  • PathwayProtein modification; protein sumoylation.
  • Sequence similaritiesBelongs to the ubiquitin-activating E1 family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activator of SUMO1 antibody
    • AOS 1 antibody
    • AOS1 antibody
    • FLJ3091 antibody
    • HSPC 140 antibody
    • HSPC140 antibody
    • SAE 1 antibody
    • Sae1 antibody
    • SAE1_HUMAN antibody
    • Sentrin/SUMO activating protein AOS 1 antibody
    • Sentrin/SUMO activating protein AOS1 antibody
    • SUA 1 antibody
    • SUA1 antibody
    • SUMO 1 activating enzyme E1 N subunit antibody
    • SUMO 1 activating enzyme subunit 1 antibody
    • SUMO-activating enzyme subunit 1 antibody
    • SUMO1 activating enzyme E1 N subunit antibody
    • SUMO1 activating enzyme subunit 1 antibody
    • Ubiquitin like 1 activating enzyme E1A antibody
    • Ubiquitin like protein SUMO 1 activating enzyme antibody
    • Ubiquitin like protein SUMO1 activating enzyme antibody
    • Ubiquitin-like 1-activating enzyme E1A antibody
    • UBL E1A antibody
    • UBLE 1A antibody
    • UBLE1A antibody
    see all

Anti-SAE1 antibody images

  • Anti-SAE1 antibody (ab38434) + Mouse heart tissue lysate

    Predicted band size : 38 kDa
    Additional bands at : 59 kDa,70 kDa,75 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ab38434, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining

References for Anti-SAE1 antibody (ab38434)

ab38434 has not yet been referenced specifically in any publications.

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