|
|
|
|
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SAFB antibody (ab84378)
(enlarge)
|
|
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SAFB antibody (ab84378)
(enlarge)
|
|
|
|
|
Product Name
|
SAFB antibody
|
| |
See all SAFB antibodies (3)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Rabbit polyclonal to SAFB
|
|
Immunogen
|
Synthetic peptide, corresponding to a region within residues 875 and the C-terminus (residue 915) of human SAFB (NP_002958.2).
|
|
Reacts with
(species key)
|
Hu, Ms
|
|
Tested applications
(see key)
|
IHC-P
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
IHC-P: 1/100 - 1/500.
Antigen exposure is recommended.
Antigen exposure with citrate buffer will enhance staining.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Positive control
(see definition)
|
Human breast adenocarcinoma.
Mouse squamous cell carcinoma.
|
|
Cellular localization
|
Nuclear
|
|
Research areas
|
Chromatin and Nuclear Signaling >> Chromosome Structure >> Scaffold Proteins
|
|
Relevance
|
SAFB (Scaffold Attachment Factor-B) is a member of a subset of nuclear matrix proteins that mediate the attachment of chromatin to nuclear protein complexes however it is not part of the nuclear matrix.
SAFB is ubiquitously expressed and appears to be a multifunctional protein involved in chromatin organization, mRNA processing and transcriptional regulation. It is expressed at high levels in the CNS and at low levels in the liver. Also expressed in a wide number of breast cancer cell lines.
SAFB has been demonstrated to interact with and function as a corepressor with many nuclear receptors such as estrogen receptor-alpha, PPAR-gamma, and FXR-alpha.
|
|
|
|
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Rabbit
|
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Purity
|
Immunogen affinity purified
|
|
Storage buffer
|
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
|
|
Form
|
Liquid
|
|
Storage instructions
|
Store at +4°C.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this SAFB antibody is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
|
See below for SAFB antibody images, references, products related to ab84378 and other tools.
|
| |
SAFB antibody images:
|
 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SAFB antibody (ab84378)
ab84378 at 1/250, staining human SAFB in a section of human breast adenocarcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
|
| |
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SAFB antibody (ab84378)
ab84378 at 1/250 dilution, staining SAFB in FFPE section of mouse squamous cell carcinoma, by immunohistochemistry (formalin/PFA-fixed parafin-embedded sections)
|
| |
| |
|
Search PubMed (MEDLINE) for references to SAFB
|
| |
SAFB antibody - more information
|
Customer reviews (feedback) regarding SAFB antibody |
Customer FAQs regarding SAFB antibody |
Protocols for SAFB antibody |
Price and availability of products related to SAFB antibody |
| |
SAFB antibody - related products:
|
|
|
| |
SAFB antibody - other tools:
|
Contact Abcam with a Technical Enquiry about SAFB antibody |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
