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Overview
Product name
Anti-SAFB antibody
See all SAFB products (5) ...
Description
Rabbit polyclonal to SAFB
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide, corresponding to a region within residues 875 and the C-terminus (residue 915) of human SAFB (NP_002958.2).
Positive control
Human breast adenocarcinoma. Mouse squamous cell carcinoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Chromosome Structure >> Scaffold Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab84378 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 2 Images
IHC-P
Application notes
IHC-P: 1/100 - 1/500.
Antigen exposure is recommended.
Antigen exposure with citrate buffer will enhance staining.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation.
Tissue specificity
Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
Sequence similarities
Contains 1 RRM (RNA recognition motif) domain.
Contains 1 SAP domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ15424
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DKFZp779C1727 antibody
- glutathione S transferase fusion protein antibody
- HAP antibody
see all
Database links
- Entrez Gene: 6294 Human
- Entrez Gene: 224903 Mouse
- Omim: 602895 Human
- SwissProt: Q15424 Human
- SwissProt: Q80YR5 Mouse
- Unigene: 728802 Human
- Unigene: 255066 Mouse
Anti-SAFB antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SAFB antibody (ab84378)
ab84378 at 1/250, staining human SAFB in a section of human breast adenocarcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SAFB antibody (ab84378)
ab84378 at 1/250 dilution, staining SAFB in FFPE section of mouse squamous cell carcinoma, by immunohistochemistry (formalin/PFA-fixed parafin-embedded sections)
References for Anti-SAFB antibody (ab84378)
ab84378 has not yet been referenced specifically in any publications.
Publishing research using ab84378? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"