SAMSN1 antibody (ab21206)

Product Name 

SAMSN1 antibody

Product type 

Primary antibodies

Description 

Goat polyclonal to SAMSN1

Immunogen 

Synthetic peptide: IRLDTLSASLGRS-C (Human)

Please note that the immunogen sequence is present in NP_071419.2 (and in
AAK07746) but is no longer present in the latest reference sequence
(NP_071419.3 at 05/10/05). This latest version has not been subject to final review by NCBI. This antibody may be recognising one particular isoform.
BLAST 'IRLDTLSASLGRS-C' with or

Reacts with 
(species key)

Hu

Tested applications 
(see key)

ELISA, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution. The antibody detection limit dilution is 1:64,000 in a peptide ELISA.
WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 48 kDa in Jurkat cell lysates (predicted molecular weight: 42 kDa). The observed size is consistent with observations with competing products.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Jurkat lysate

Cellular localization 

Cytoplasmic

Research areas 

Stem Cells >> Hematopoietic Progenitors >> Intracellular Molecules
Signal Transduction >> Adapters >> Cytoplasmic

Relevance 

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains. It also contains several predicted consensus nuclear localization signals and a tyrosine kinase phosphorylation motif. Northern blot analysis has revealed expression of a 2.2kb SAMSN1 transcript in human immune tissues and hematopoietic cell types including normal bone marrow, acute myeloid leukemia, and multiple myeloma; low-level expression was seen in other tissues such as heart, brain, placenta, and lung.
SAMSN1 has been shown to be up-regulated by B cell activation signals and is a participant in B cell activation and differentiation.

Database links 

Raised in 

Goat

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline. pH 7.3

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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