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Product name
Anti-SARM antibody
See all SARM products (2) ...
Description
Rabbit polyclonal to SARM
Tested applications
WB, ICC/IFmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide (Human) (C terminal).
Positive control
Daudi cells
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Other Antibodies >> Other Antibodies
Signal Transduction >> Growth Factors/Hormones >> Hormones
Immunology >> Innate Immunity >> Cytokines >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab17812 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 80 kDa.
ICC/IF: Use a concentration of 2 µg/ml.
Target
Function
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Tissue specificity
Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
Sequence similarities
Contains 2 SAM (sterile alpha motif) domains.
Contains 1 TIR domain.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ6SZW1
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- FLJ36296 antibody
- KIAA0524 antibody
- SAM and ARM-containing protein antibody
see all
Database links
- Entrez Gene: 23098 Human
- Entrez Gene: 237868 Mouse
- Omim: 607732 Human
- SwissProt: Q6SZW1 Human
- SwissProt: Q6PDS3 Mouse
- Unigene: 446689 Human
- Unigene: 210332 Mouse
Anti-SARM antibody images:
Western blot - SARM antibody (ab17812)
Lane 1 : Anti-SARM antibody (ab17812) at 0.5 µg/ml
Lane 2 : Anti-SARM antibody (ab17812) at 1 µg/ml
Lane 3 : Anti-SARM antibody (ab17812) at 2 µg/ml
Lane 1 : Daudi cell lysate
Lane 2 : Daudi cell lysate
Lane 3 : Daudi cell lysate
Predicted band size : 80 kDa
Observed band size : 80 kDa
Immunocytochemistry/ Immunofluorescence - SARM antibody (ab17812)
ab17812 at 2µg/ml staining of SARM in Daudi cells by ICC/IF
References for Anti-SARM antibody (ab17812)
This product has been referenced in:
- de Vos AF et al. In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands. J Immunol 183:533-42 (2009). WB; Human.Read more (PubMed: 19542464) »
See 1 publication for this product
Publishing research using ab17812? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"