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Products:Cell Biology >> Cell Cycle >> Cell differentiation
Overview
Product name
SART1 peptide (2-14)
Protein description
Synthetic peptide: GSSKKHRGEKEAA-C, corresponding to N terminal amino acids 2-14 of Human SART1. This peptide was used as an immunogen for ab22820 - SART1 antibody.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Concentration
Concentration information loading...
Sequence
GSSKKHRGEK EAA-C
Research areas
Cancer >> Cell cycle >> Cell differentiation
Cell Biology >> Cell Cycle >> Cell differentiation
Protein info
Relevance
SART1 encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri snRNP to the pre spliceosome in the spliceosome assembly pathway.
Cellular localization
Nuclear
References for SART1 peptide (2-14) (ab45491)
ab45491 has not yet been referenced specifically in any publications.
Publishing research using ab45491? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"