SB 399885 hydrochloride (ab120332)
- Product nameSB 399885 hydrochloride
- DescriptionPotent, selective 5HT6 antagonist
- Biological descriptionPotent, selective competitive 5HT6 antagonist (pKi values are 8.81 and 9.02 for rat and human native receptors respectively). Orally active, cognitive enhancer in vivo. Displays > 200-fold selectivity over 5-HT1A, 5HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4, 5-HT7, α1B, D2, D3, D4 receptors, ion channels and a range of enzymes.
- Purity> 99%
- Chemical nameN-(3,5-dichloro-2-methoxy-phenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide hydrochloride
- Molecular Weight482.81
- Chemical structure
- Molecular formulaC18H21Cl2N3O4S.HCl
- CAS Number402713-80-8
- PubChem identifier10277652
- Storage instructionsStore at room temperature (desiccating conditions).
- Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for SB 399885 hydrochloride (ab120332)
This product has been referenced in:
- Wesolowska A & Nikiforuk A Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52:1274-83 (2007). Read more (PubMed: 17320917) »
- Hirst WD et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol 553:109-19 (2006). Read more (PubMed: 17069795) »
- Perez-García G & Meneses A Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol Biochem Behav 81:673-82 (2005). Read more (PubMed: 15964617) »