AbcamBiochemicals

SB 399885 hydrochloride (ab120332)

Overview

  • Product nameSB 399885 hydrochloride
  • Description
    Potent, selective 5HT6 antagonist
  • Biological descriptionPotent, selective competitive 5HT6 antagonist (pKi values are 8.81 and 9.02 for rat and human native receptors, respectively). Orally active, cognitive enhancer in vivo. Displays > 200-fold selectivity over 5-HT1A, 5HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4, 5-HT7, α1B, D2, D3, D4 receptors, ion channels and a range of enzymes.
  • Purity> 99%

Properties

    References for SB 399885 hydrochloride (ab120332)

    This product has been referenced in:
    • Wesolowska A & Nikiforuk A Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52:1274-83 (2007). Read more (PubMed: 17320917) »
    • Hirst WD  et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol 553:109-19 (2006). Read more (PubMed: 17069795) »
    • Perez-García G & Meneses A Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol Biochem Behav 81:673-82 (2005). Read more (PubMed: 15964617) »

    See 0 Publications for this product

    Product Wall

    Thank you for bringing this to our attention. The following link will bring you to an FAQ page that addresses your concerns. It is a good resource for answering questions about our biochemicals in general.

    http://www.abcam.com/index.html?pag...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"