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Product name
SB431542
Description
ALK inhibitor
Biological description
Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide
Molecular Weight
384.39
Chemical structure
Molecular formula
C22H16N4O3
CAS Number
301836-41-9
Solubility
Soluble in DMSO to 100 mM and in ethanol to 10 mM
Storage instructions
Store at room temperature (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> ALK >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for SB431542 (ab120163)
This product has been referenced in:
- Halder SK et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7:509-21 (2005).Read more (PubMed: 15967103) »
- Laping NJ et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol 62:58-64 (2002).Read more (PubMed: 12065755) »
See all 3 publications for this product
Publishing research using ab120163? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"