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Products:Tags & Cell Markers >> Subcellular Markers >> Organelles >> Mitochondria
Overview
Product name
Anti-SCO2 antibody
See all SCO2 products (2) ...
Description
Rabbit polyclonal to SCO2
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
A 19 amino acid synthetic peptide from near the carboxy terminus of human SCO2.
Positive control
Human liver tissue lysate
Properties
Form
Liquid
Storage instructions
Store at 4°C for up to one year. Upon use, aliquot and store at -20°C or -80°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Metabolism >> Vitamins / Minerals
Signal Transduction >> Metabolism >> Mitochondrial
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Mitochondria
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Western blot - SCO2 antibody (ab58814)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58814 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml.Detects a band of approximately 54 kDa (predicted molecular weight: 30 kDa).
Target
Function
Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
Tissue specificity
Ubiquitous.
Involvement in disease
Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
Sequence similarities
Belongs to the SCO1/2 family.
Contains 1 thioredoxin domain.
Cellular localization
Mitochondrion.
Target information above from: UniProt accessionO43819
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- mitochondrial antibody
- Cytochrome oxidase deficient homolog 2 antibody
- MGC125823 antibody
see all
Database links
- Entrez Gene: 9997 Human
- Omim: 604272 Human
- SwissProt: O43819 Human
- Unigene: 180903 Human
Anti-SCO2 antibody images:
Western blot - SCO2 antibody (ab58814)
Lane 1 : Anti-SCO2 antibody (ab58814) at 0.5 µg/ml
Lane 2 : Anti-SCO2 antibody (ab58814) at 1 µg/ml
Lane 3 : Anti-SCO2 antibody (ab58814) at 2 µg/ml
Lane 1 : human liver tissue lysate
Lane 2 : human liver tissue lysate
Lane 3 : human liver tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 30 kDa
Observed band size : ~50 kDa (why is the actual band size different from the predicted?)
The difference in size is thought to be a modification in the protein.
References for Anti-SCO2 antibody (ab58814)
ab58814 has not yet been referenced specifically in any publications.
Publishing research using ab58814? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"