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Product Name
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SCO2 protein
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Product type
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Proteins and Peptides
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Peptide
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Recombinant fragment (Human). The protein consists of the soluble domain (aa 100-266) of apo-HSCO2, which lacks the transmembrane segment. (NCBI accession NP_005129). MW = 19.5 kDa.
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Tested applications
(see key)
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Signal Transduction >> Metabolism >> Vitamins / Minerals
Signal Transduction >> Metabolism >> Mitochondrial
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Mitochondria
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Relevance
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SCO2 (Synthesis of cytochrome c oxidase 2) was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, results in a drop in SCO2 expression which leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency, a disease characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis.
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 50% Potassium Di-Hydrogen Ortho Phosphate/ Di-Potassium Hydrogen Ortho Phosphate, 1mM DTT, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at -20°C, Stable for 6 months at -20°C
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Expression system
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E. coli
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this SCO2 protein is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to SCO2
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SCO2 protein - more information
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Customer reviews (feedback) regarding SCO2 protein |
Customer FAQs regarding SCO2 protein |
Protocols for SCO2 protein |
Price and availability of products related to SCO2 protein |
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