FunctionProtease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
Tissue specificityHighly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Sequence similaritiesBelongs to the peptidase C48 family.
Cellular localizationNucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.
Western blot analysis SENP 1 in whole HL60 cell lysate. SENP1 (Arrow) was detected using ab3656 (Lane B) but not pre-immune serum (lane A). Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
References for Anti-SENP1 antibody (ab3656)
This product has been referenced in:
Ni RS et al. Detection of differentially expressed genes and association with clinicopathological features in laryngeal squamous cell carcinoma. Oncol Lett4:1354-1360 (2012).
Read more (PubMed: 23226807) »
Dai XQ et al. SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes60:838-47 (2011).
Read more (PubMed: 21266332) »