Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab3656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notesWestern blotting: 1/100 - 1/500.
    ELISA: 1/1000.
    Not tested in other applications.

    Optimal dilutions / concentrations should be determined by the end user.

    Expected molecular weight: 73.351 kDa (from SwissProt Q9P0U3).
  • Target

    • FunctionProtease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
    • Tissue specificityHighly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
    • Sequence similaritiesBelongs to the peptidase C48 family.
    • Cellular localizationNucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • SENP 1 antibody
      • SENP1 antibody
      • SENP1_HUMAN antibody
      • Sentrin specific protease 1 antibody
      • Sentrin-specific protease 1 antibody
      • Sentrin/SUMO specific protease 1 antibody
      • Sentrin/SUMO specific protease antibody
      • Sentrin/SUMO specific protease SENP 1 antibody
      • Sentrin/SUMO specific protease SENP1 antibody
      • Sentrin/SUMO-specific protease SENP1 antibody
      • SUMO1/sentrin specific peptidase 1 antibody
      • SuPr 2 antibody
      • SuPr2 antibody
      see all

    Anti-SENP1 antibody images

    • Western blot analysis SENP 1 in whole HL60 cell lysate. SENP1 (Arrow) was detected using ab3656 (Lane B) but not pre-immune serum (lane A). Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

    References for Anti-SENP1 antibody (ab3656)

    This product has been referenced in:
    • Ni RS  et al. Detection of differentially expressed genes and association with clinicopathological features in laryngeal squamous cell carcinoma. Oncol Lett 4:1354-1360 (2012). WB ; Human . Read more (PubMed: 23226807) »
    • Dai XQ  et al. SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes 60:838-47 (2011). WB ; Human, Mouse . Read more (PubMed: 21266332) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"