Anti-SENP2 antibody (ab3660)
Overview
- Product nameAnti-SENP2 antibodySee all SENP2 primary antibodies ...
- DescriptionRabbit polyclonal to SENP2
- Tested applicationsWB, ELISA, IHC-P more details
- Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat - Immunogen
Synthetic peptide: KTKRNSDLNLLEWTHHS, corresponding to amino acids 517-533 of Human SENP 2.
- Positive controlHL60 whole cell lysate.
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPBS with 0.1% sodium azide
-
Concentration information loading... - PurityProtein G purified
- Purification notesThis antibody is purified through a protein G column and eluted out with both high and low pH buffers. It is neutralized immediately after elution, followed by dialysis against PBS.
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab3660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | |
| ELISA | |
| IHC-P |
IHC-P: 1/50 - 1/100.
WB: 1/100 - 1/500.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Expected molecular weight: 67.952 kDa (SwissProt Q9HC62).
Target
- FunctionProtease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
- Sequence similaritiesBelongs to the peptidase C48 family.
- DomainThe N-terminus is necessary and sufficient for nuclear envelope targeting.
- Post-translational
modificationsPolyubiquitinated; which leads to proteasomal degradation. - Cellular localizationNucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
-
Database links
- Entrez Gene: 59343 Human
- Entrez Gene: 75826 Mouse
- Entrez Gene: 78973 Rat
- Omim: 608261 Human
- SwissProt: Q9HC62 Human
- SwissProt: Q91ZX6 Mouse
- SwissProt: Q9EQE1 Rat
- Unigene: 401388 Human
- Unigene: 297431 Mouse
- Unigene: 9367 Rat
see all
Target information above from: UniProt accession
Q9HC62
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
.
-
Alternative names
- Axam2 antibodyDKFZp762A2316 antibodyKIAA1331 antibody
- Senp2 antibodySENP2_HUMAN antibodySentrin specific protease 2 antibodySentrin-specific protease 2 antibodySentrin/SUMO specific protease SENP2 antibodySentrin/SUMO-specific protease SENP2 antibodySMT3 specific isopeptidase 2 antibodySMT3-specific isopeptidase 2 antibodySmt3ip2 antibodySUMO1/sentrin/SMT3 specific peptidase 2 antibody
see all
Anti-SENP2 antibody images
-
Western blot - SENP2 antibody (ab3660)ab3660 at a 1/100 dilution staining approximately 68 kDa band of SENP2 in Jurkat cell lysate by Western blot (ECL). -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP2 antibody (ab3660)ab3660 staining SENP2 in human breast carcinoma (BC) tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
References for Anti-SENP2 antibody (ab3660)
This product has been referenced in:
- Jones MC et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A 103:16272-7 (2006). Read more (PubMed: 17053081) »
