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- Proteins and Peptides
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Product name
Anti-SENP2 antibody
See all SENP2 products (6) ...
Description
Rabbit polyclonal to SENP2
Tested applications
WB, ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide: KTKRNSDLNLLEWTHHS, corresponding to amino acids 517-533 of Human SENP 2.
KTKRNSDLNLLEWTHHS
Positive control
HL60 whole cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.1% sodium azide
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
This antibody is purified through a protein G column and eluted out with both high and low pH buffers. It is neutralized immediately after elution, followed by dialysis against PBS.
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3660 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
- 1 Image
IHC-P
Application notes
ELISA: 1/1000.
IHC-P: 1/50 - 1/100.
WB: 1/100 - 1/500.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Expected molecular weight: 67.952 kDa (SwissProt Q9HC62).
Target
Function
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
Sequence similarities
Belongs to the peptidase C48 family.
Domain
The N-terminus is necessary and sufficient for nuclear envelope targeting.
Post-translational
modifications
Polyubiquitinated; which leads to proteasomal degradation.
Cellular localization
Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
Target information above from: UniProt accessionQ9HC62
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Axam2 antibody
- DKFZp762A2316 antibody
- KIAA1331 antibody
see all
Database links
- Entrez Gene: 59343 Human
- Entrez Gene: 75826 Mouse
- Entrez Gene: 78973 Rat
- Omim: 608261 Human
- SwissProt: Q8IW97 Human
- SwissProt: Q9HC62 Human
- SwissProt: Q544T8 Mouse
- SwissProt: Q91ZX6 Mouse
see all
Anti-SENP2 antibody images:
Western blot - SENP2 antibody (ab3660)
ab3660 at a 1/100 dilution staining approximately 68 kDa band of SENP2 in Jurkat cell lysate by Western blot (ECL).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP2 antibody (ab3660)
ab3660 staining SENP2 in human breast carcinoma (BC) tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
References for Anti-SENP2 antibody (ab3660)
This product has been referenced in:
- Jones MC et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A 103:16272-7 (2006).Read more (PubMed: 17053081) »
See 1 publication for this product
Publishing research using ab3660? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"