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Anti-SENP2 antibody (ab3660)

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Overview

Product name

Anti-SENP2 antibody
See all SENP2 products (6) ...

Description

Rabbit polyclonal to SENP2

Tested applications

WB, ELISA, IHC-Pmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat

Immunogen

Synthetic peptide: KTKRNSDLNLLEWTHHS, corresponding to amino acids 517-533 of Human SENP 2.

KTKRNSDLNLLEWTHHS

Positive control

HL60 whole cell lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.1% sodium azide

Concentration

Concentration information loading...

Purity

Protein G purified

Purification notes

This antibody is purified through a protein G column and eluted out with both high and low pH buffers. It is neutralized immediately after elution, followed by dialysis against PBS.

Clonality

Polyclonal

Isotype

IgG

  • Western blot - SENP2 antibody (ab3660)Western blot - SENP2 antibody (ab3660) image (enlarge)

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP2 antibody (ab3660)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP2 antibody (ab3660) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab3660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

ELISA: 1/1000.
IHC-P: 1/50 - 1/100.
WB: 1/100 - 1/500.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Expected molecular weight: 67.952 kDa (SwissProt Q9HC62).

Target

Function

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.

Sequence similarities

Belongs to the peptidase C48 family.

Domain

The N-terminus is necessary and sufficient for nuclear envelope targeting.

Post-translational
modifications

Polyubiquitinated; which leads to proteasomal degradation.

Cellular localization

Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.

Target information above from: UniProt accessionQ9HC62 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Axam2 antibody
  • DKFZp762A2316 antibody
  • KIAA1331 antibody
  • Senp2 antibody
  • SENP2_HUMAN antibody
  • Sentrin specific protease 2 antibody
  • Sentrin-specific protease 2 antibody
  • Sentrin/SUMO specific protease SENP2 antibody
  • Sentrin/SUMO-specific protease SENP2 antibody
  • SMT3 specific isopeptidase 2 antibody
  • SMT3-specific isopeptidase 2 antibody
  • Smt3ip2 antibody
  • SUMO1/sentrin/SMT3 specific peptidase 2 antibody
see all

Anti-SENP2 antibody images:

  Western blot - SENP2 antibody (ab3660)

Western blot - SENP2 antibody (ab3660)

ab3660 at a 1/100 dilution staining approximately 68 kDa band of SENP2 in Jurkat cell lysate by Western blot (ECL).

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP2 antibody (ab3660)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP2 antibody (ab3660)

ab3660 staining SENP2 in human breast carcinoma (BC) tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

References for Anti-SENP2 antibody (ab3660)

This product has been referenced in:

  • Jones MC  et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A 103:16272-7 (2006).Read more (PubMed: 17053081) »

See 1 publication for this product

Publishing research using ab3660? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"