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Products:Immunology >> Innate Immunity >> Cytokines >> Interleukins
Overview
Product name
Anti-SIGIRR antibody
See all SIGIRR products (7) ...
Description
Rabbit polyclonal to SIGIRR
Specificity
ab25875 recognises SIGIRR.
Tested applications
ICC/IF, WBmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to 15 amino acids at the C terminus of Mouse SIGIRR.
Positive control
A549 cell lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab25875 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use a concentration of 10 µg/ml
WB: Use a concentration of 0.5 - 1 µg/ml.Predicted molecular weight: 47 kDa.
Target
Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificity
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ6IA17
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Single immunoglobulin domain containing IL1R related protein antibody
- TIR8 antibody
- Toll/interleukin 1 receptor 8 antibody
see all
Database links
- Entrez Gene: 59307 Human
- Entrez Gene: 24058 Mouse
- Omim: 605478 Human
- SwissProt: Q6IA17 Human
- SwissProt: Q9JLZ8 Mouse
- Unigene: 501624 Human
- Unigene: 38017 Mouse
Anti-SIGIRR antibody images:
Western blot - SIGIRR antibody (ab25875)
Predicted band size : 47 kDa
Western blot analysis of SIGIRR in A549 cell lysate with anti-SIGIRR (CT) at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry - SIGIRR antibody (ab25875)
ab25875 at 10µg/ml in A549 staining SIGIRR in A549 cells by ICC/IF
References for Anti-SIGIRR antibody (ab25875)
ab25875 has not yet been referenced specifically in any publications.
Publishing research using ab25875? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"