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Anti-SIGIRR antibody (ab25875)

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Overview

Product name

Anti-SIGIRR antibody
See all SIGIRR products (7) ...

Description

Rabbit polyclonal to SIGIRR

Specificity

ab25875 recognises SIGIRR.

Tested applications

ICC/IF, WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Synthetic peptide corresponding to 15 amino acids at the C terminus of Mouse SIGIRR.

Positive control

A549 cell lysate

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - SIGIRR antibody (ab25875)Western blot - SIGIRR antibody (ab25875) image (enlarge)

  • Immunohistochemistry - SIGIRR antibody (ab25875)Immunohistochemistry - SIGIRR antibody (ab25875) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Tissue specificity

Mainly expressed in epithelial tissues such as kidney, lung and gut.

Sequence similarities

Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ6IA17 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Single immunoglobulin domain containing IL1R related protein antibody
  • TIR8 antibody
  • Toll/interleukin 1 receptor 8 antibody
  • Ig IL1 related receptor antibody
  • MGC110992 antibody
  • SIGIR_HUMAN antibody
  • SIGIRR antibody
  • Single Ig IL 1 related receptor antibody
  • Single Ig IL-1-related receptor antibody
  • Single Ig IL-1R-related molecule antibody
  • Single Ig IL1R Related Molecule antibody
  • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
  • Single immunoglobulin and toll interleukin 1 receptor domain antibody
  • Single immunoglobulin domain containing IL1R related protein antibody
  • Single immunoglobulin domain IL1R1 related antibody
  • Single immunoglobulin domain-containing IL1R-related protein antibody
  • TIR 8 antibody
  • TIR8 antibody
  • Toll/interleukin 1 receptor 8 antibody
  • Toll/interleukin-1 receptor 8 antibody
see all

Anti-SIGIRR antibody images:

  Western blot - SIGIRR antibody (ab25875)

Western blot - SIGIRR antibody (ab25875)



Predicted band size : 47 kDa


Western blot analysis of SIGIRR in A549 cell lysate with anti-SIGIRR (CT) at (A) 0.5, (B) 1, and (C) 2 ug/ml.

  Immunohistochemistry - SIGIRR antibody (ab25875)

Immunohistochemistry - SIGIRR antibody (ab25875)

ab25875 at 10µg/ml in A549 staining SIGIRR in A549 cells by ICC/IF

References for Anti-SIGIRR antibody (ab25875)

ab25875 has not yet been referenced specifically in any publications.

Publishing research using ab25875? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"