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Products:Immunology >> Innate Immunity >> Cytokines >> Interleukins
Overview
Product name
Anti-SIGIRR antibody
See all SIGIRR products (7) ...
Description
Rabbit polyclonal to SIGIRR
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Chicken, Cow, Zebrafish
Immunogen
Synthetic peptide corresponding to a region of human SIGIRR (XP_001129013)
Positive control
Jurkat cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Immunology >> Innate Immunity >> Cytokines >> Interleukins
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Western blot - SIGIRR antibody (ab76401)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab76401 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
ELISA
Application notes
ELISA: Use at an assay dependent dilution. Titre using peptide based assay, 1:62500.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificity
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ6IA17
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Single immunoglobulin domain containing IL1R related protein antibody
- TIR8 antibody
- Toll/interleukin 1 receptor 8 antibody
see all
Database links
- Entrez Gene: 59307 Human
- Entrez Gene: 24058 Mouse
- Entrez Gene: 309106 Rat
- Omim: 605478 Human
- SwissProt: Q6IA17 Human
- SwissProt: Q9JLZ8 Mouse
- SwissProt: Q4V892 Rat
- Unigene: 501624 Human
see all
Anti-SIGIRR antibody images:
Western blot - SIGIRR antibody (ab76401)
Anti-SIGIRR antibody (ab76401) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg
Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 25 kDa
References for Anti-SIGIRR antibody (ab76401)
ab76401 has not yet been referenced specifically in any publications.
Publishing research using ab76401? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"