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Anti-SIGIRR antibody (ab76401)

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Overview

Product name

Anti-SIGIRR antibody
See all SIGIRR products (7) ...

Description

Rabbit polyclonal to SIGIRR

Tested applications

WB, ELISAmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat, Chicken, Cow, Zebrafish

Immunogen

Synthetic peptide corresponding to a region of human SIGIRR (XP_001129013)

Positive control

Jurkat cell lysate

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 2% Sucrose, PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - SIGIRR antibody (ab76401)Western blot - SIGIRR antibody (ab76401) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab76401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

ELISA: Use at an assay dependent dilution. Titre using peptide based assay, 1:62500.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Tissue specificity

Mainly expressed in epithelial tissues such as kidney, lung and gut.

Sequence similarities

Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ6IA17 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Single immunoglobulin domain containing IL1R related protein antibody
  • TIR8 antibody
  • Toll/interleukin 1 receptor 8 antibody
  • Ig IL1 related receptor antibody
  • MGC110992 antibody
  • SIGIR_HUMAN antibody
  • SIGIRR antibody
  • Single Ig IL 1 related receptor antibody
  • Single Ig IL-1-related receptor antibody
  • Single Ig IL-1R-related molecule antibody
  • Single Ig IL1R Related Molecule antibody
  • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
  • Single immunoglobulin and toll interleukin 1 receptor domain antibody
  • Single immunoglobulin domain IL1R1 related antibody
  • Single immunoglobulin domain-containing IL1R-related protein antibody
  • TIR 8 antibody
  • Toll/interleukin-1 receptor 8 antibody
see all

Anti-SIGIRR antibody images:

  Western blot - SIGIRR antibody (ab76401)

Western blot - SIGIRR antibody (ab76401)

Anti-SIGIRR antibody (ab76401) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution

Predicted band size : 25 kDa

References for Anti-SIGIRR antibody (ab76401)

ab76401 has not yet been referenced specifically in any publications.

Publishing research using ab76401? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"