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Products:Immunology >> Innate Immunity >> Cytokines >> Interleukins
Overview
Product name
Anti-SIGIRR antibody
See all SIGIRR products (7) ...
Description
Rabbit polyclonal to SIGIRR
Tested applications
WB, IHC-Frmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
A synthetic peptide corresponding to 15 amino acids at the carboxy terminus of mouse SIGIRR.
Positive control
A549 cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified IgG was prepared from whole serum by immunoaffinity chromatography.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab81516 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml.Detects a band of approximately 43 kDa (predicted molecular weight: 46 kDa).
IHC-Fr: Use a concentration of 10 µg/ml
Target
Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificity
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ6IA17
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Single immunoglobulin domain containing IL1R related protein antibody
- TIR8 antibody
- Toll/interleukin 1 receptor 8 antibody
see all
Database links
- Entrez Gene: 59307 Human
- Entrez Gene: 24058 Mouse
- Omim: 605478 Human
- SwissProt: Q6IA17 Human
- SwissProt: Q9JLZ8 Mouse
- Unigene: 501624 Human
- Unigene: 38017 Mouse
References for Anti-SIGIRR antibody (ab81516)
ab81516 has not yet been referenced specifically in any publications.
Publishing research using ab81516? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"