Anti-SIGLEC8 antibody - Aminoterminal end (ab38579)

Overview

• Product nameAnti-SIGLEC8 antibody - Aminoterminal endSee all SIGLEC8 primary antibodies ...
• Description
  Rabbit polyclonal to SIGLEC8 - Aminoterminal end
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide (10-30 aa in length) at the N-term of first 50 aa of human SIGLEC8 conjugated to KLH.

• Positive controlHL 60 cell lysate

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Vascular

  • Immunology
  • Immunoglobulins
  • Receptors

  • Immunology
  • Cell Type Markers
  • CD
  • Adhesion

Applications

Target

• RelevanceSIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
• Cellular localizationCell Membrane; single pass type I membrane protein
• Database links
  • Entrez Gene: 27181 Human
  • Entrez Gene: 27181 Human
  • Omim: 605639 Human
  • SwissProt: Q9NYZ4 Human
  • SwissProt: Q9NYZ4 Human

• Alternative names
  CD329 antigen antibodyCDw329 antibodySAF 2 antibody

  SAF2 antibodySialic acid binding Ig like lectin 8 antibodySialoadhesin family member 2 antibodySiglec 8 antibodySIGLEC8 antibodySIGLEC8L antibody

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Anti-SIGLEC8 antibody - Aminoterminal end images

• 

  Western blot - SIGLEC8 antibody - Aminoterminal end (ab38579)
  Anti-SIGLEC8 antibody - Aminoterminal end (ab38579) at 1/100 dilution + HL60 cell lysate
  
  Predicted band size : 54 kDa
  Observed band size : 54 kDa
  Additional bands at : 22 kDa. We are unsure as to the identity of these extra bands.