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Products:Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol I Transcription
Overview
Product name
Anti-SIRT7 antibody
See all SIRT7 products (3) ...
Description
Rabbit polyclonal to SIRT7
Tested applications
Cross reactivity
Reacts with
Human
Does not react with
Mouse, Rat
Immunogen
Synthetic peptides: ILRKAAAERSAEEGRLL & CRSREEAPPGDRGAPLS corresponding to amino acids 35-51 & 361-377 of Human SIRT7.
ILRKAAAERS AEEGRLL
Positive control
Human liver tissue lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS, 1mg/ml BSA
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
This antibody is affinity purified.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Heart >> Cardiac metabolism
Cardiovascular >> Atherosclerosis >> Apoptosis
Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Transcription factors
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HDACs >> Class III / Sir2 class
Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Epigenetics and Nuclear Signaling >> Transcription >> Co-factors
Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol I Transcription
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Western blot - SIRT7 antibody (ab13682)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab13682 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 48 kDa.
Target
Function
NAD-dependent protein deacetylase. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex.
Sequence similarities
Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
Post-translational
modifications
Phosphorylated during mitosis.
Cellular localization
Cytoplasm. Nucleus > nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
Target information above from: UniProt accessionQ9NRC8
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- MGC126840 antibody
- MGC126842 antibody
- NAD dependent deacetylase sirtuin 7 antibody
see all
Database links
- Entrez Gene: 51547 Human
- Omim: 606212 Human
- SwissProt: Q9NRC8 Human
- Unigene: 514636 Human
Anti-SIRT7 antibody images:
Western blot - SIRT7 antibody (ab13682)
Predicted band size : 48 kDa
Western blot analysis for SIRT7 using ab13682 at 1 µg/ml against 15 µg of human liver lysate.
References for Anti-SIRT7 antibody (ab13682)
ab13682 has not yet been referenced specifically in any publications.
Publishing research using ab13682? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"