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Western blot - SIRT7 antibody (ab13682)
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Product Name
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SIRT7 antibody
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See all SIRT7 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to SIRT7
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Immunogen
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Synthetic peptides: ILRKAAAERSAEEGRLL & CRSREEAPPGDRGAPLS corresponding to amino acids 35-51 & 361-377 of Human SIRT7.
BLAST 'ILRKAAAERSAEEGRLL' with  or 
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Reacts with
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Hu
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Does not react with
(species key)
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Ms, Rat
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Human liver tissue lysate.
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Cellular localization
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Nuclear
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Research areas
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Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Transcription factors
Chromatin and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HDACs >> Class III / Sir2 class
Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Chromatin and Nuclear Signaling >> Transcription >> Co-factors
Chromatin and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol I Transcription
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Relevance
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SIRT7, or sirtuin 7, is a member of the sirtuin family of proteins, which are Class III histone deacetylases. SIRT7 is a putative NAD-dependent deacetylase. It is a nucleolar protein that is associated with active rRNA genes and RNA polymerase I, as well as histones. Overexpression of SIRT7 increases rRNA transcription, while its down-regulation has the opposite effect. The expression of SIRT7 is enriched in metabolically active tissues such as the liver. SIRT7 gene expression is also up-regulated in some thyroid and breast cancers.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: PBS, 1mg/ml BSA Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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This antibody is affinity purified.
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this SIRT7 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for SIRT7 antibody images, references, products related to ab13682 and other tools.
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SIRT7 antibody images:
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 Western blot - SIRT7 antibody (ab13682)
Predicted band size : 48 kDa
Western blot analysis for SIRT7 using ab13682 at 1 µg/ml against 15 µg of human liver lysate.
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Search PubMed (MEDLINE) for references to SIRT7
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SIRT7 antibody - more information
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Customer reviews (feedback) regarding SIRT7 antibody |
Customer FAQs regarding SIRT7 antibody |
Protocols for SIRT7 antibody |
Price and availability of products related to SIRT7 antibody |
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SIRT7 antibody - related products:
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SIRT7 antibody - other tools:
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Contact Abcam with a Technical Enquiry about SIRT7 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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