SKF 108753 (Debromohymenialdisine) (ab143799)

Overview

  • Product name
    SKF 108753 (Debromohymenialdisine)
  • Description
    Protein kinase inhibitor. Antineoplastic agent.
  • Alternative names
    • Debromohymenialdisine
  • Biological description
    Protein kinase inhibitor. Antineoplastic agent. Inhibits Chk1 and Chk2 (IC50 values are 3 and 3.5 µM, respectively). Inhibits MAPK1 (IC50 = 881 nM) and GSK3β (IC50 = 1.39 μM). Inhibits protein tyrosine kinase 6 (IC50 = 0.6 μM). Inhibits the G2 DNA damage checkpoint (IC50 = 8 μM). Shows moderate cytotoxic effects.

Properties

References

This product has been referenced in:
  • Saleem RS  et al. Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors. Bioorg Med Chem 20:1475-81 (2012). Read more (PubMed: 22285028) »
  • Song YF  et al. Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol. Mar Biotechnol (NY) 13:868-82 (2011). Read more (PubMed: 21246234) »
  • Curman D  et al. Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. J Biol Chem 276:17914-9 (2001). Read more (PubMed: 11279124) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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