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Read our guarantee »Overview
Product name
SL 327
Description
MEK inhibitor
Biological description
Centrally active, brain penetrant selective MEK1 and MEK2 inhibitor (IC50 values in in vitro assays are 0.18 μM and 0.22 μM respectively).
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Molecular Weight
335.35
Chemical structure
Molecular formula
C16H12F3N3S
CAS Number
305350-87-2
Solubility
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> MAP kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for SL 327 (ab120082)
This product has been referenced in:
- Wang X et al. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther 304:172-8 (2003).Read more (PubMed: 12490588) »
- Scherle PA et al. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J Biol Chem 275:37086-92 (2000).Read more (PubMed: 10969080) »
See all 3 publications for this product
Publishing research using ab120082? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"