Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC34A2
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: MRSLKPWDAV VSKFTGCFQM RCCCCCRVCC RACCLLCGCP KCCRCSKCCE DLEEAQEGQD VPVKAPETFD NITISREAQG EVPASDSKTE CT, corresponding to C terminal amino acids 597-688 of Human SLC34A2 protein (UniProt ID: O95436).

  • Positive control
    • Human lung tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab122431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
  • Tissue specificity
    Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
  • Involvement in disease
    Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM) [MIM:265100]. Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
  • Sequence similarities
    Belongs to the SLC34A transporter family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Na(+)-dependent phosphate cotransporter 2B antibody
    • Na(+)/Pi cotransporter 2B antibody
    • NaPi-2b antibody
    • NaPi3b antibody
    • NPT2B_HUMAN antibody
    • SLC34A2 antibody
    • Sodium-dependent phosphate transport protein 2B antibody
    • Sodium-phosphate transport protein 2B antibody
    • Sodium/phosphate cotransporter 2B antibody
    • Solute carrier family 34 member 2 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling SLC34A2 with ab122431. Staining shows strong cytoplasmic positivity in pneumocytes.

References

ab122431 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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