Overview

  • Product nameAnti-SLIRP antibodySee all SLIRP primary antibodies ...
  • Description
    Rabbit polyclonal to SLIRP
  • Tested applicationsIHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Human

    Does not react with

    Mouse
  • Immunogen

    Synthetic peptide made to a C terminal region of human SLIRP.

  • Positive control
    • Human liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab51523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa).

Target

  • RelevanceSLIRP is a RNA binding protein that acts as a nuclear receptor corepressor. It may act by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. SLIRP binds the STR7 loop of SRA RNA. It is also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. It contains 1 RRM (RNA recognition motif) domain. SLIRP is predominantly founs in mitochondrial with a limited role in the nucleus where it is recruited to nuclear receptor target promoters.
  • Cellular localizationMitochondrial and Nuclear; Predominantly mitochondrial.
  • Database links
  • Alternative names
    • C14orf156 antibody
    • Chromosome 14 open reading frame 156 antibody
    • DC50 antibody
    • PD04872 antibody
    • SLIRP antibody
    • SRA stem loop interacting RNA binding protein, mitochondrial antibody
    see all

Anti-SLIRP antibody images

  • Anti-SLIRP antibody (ab51523) at 0.6 µg/ml + human liver lysate

    Predicted band size : 12 kDa
    Observed band size : 12 kDa

References for Anti-SLIRP antibody (ab51523)

This product has been referenced in:
  • Clemente P  et al. hCOA3 stabilizes cytochrome c oxidase 1 (COX1) and promotes cytochrome c oxidase assembly in human mitochondria. J Biol Chem 288:8321-31 (2013). Read more (PubMed: 23362268) »
  • Bayat V  et al. Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans. PLoS Biol 10:e1001288 (2012). WB ; Human . Read more (PubMed: 22448145) »

See all 5 Publications for this product

Product Wall

Application Immunohistochemistry (Frozen sections)
Sample Human Tissue sections (Normal skeletal muscle)
Specification Normal skeletal muscle
Fixative None
Permeabilization No
Username

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Verified customer

Submitted Mar 29 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"