Overview
- Product nameAnti-SLIRP antibodySee all SLIRP primary antibodies ...
- DescriptionRabbit polyclonal to SLIRP
- Tested applicationsIHC-Fr, WB more details
- Species reactivityReacts with: Human
Does not react with
Mouse - Immunogen
Synthetic peptide made to a C terminal region of human SLIRP.
- Positive controlHuman liver lysate
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.05% Sodium Azide
Constituents: Tris glycine, 150mM Sodium chloride -
Concentration information loading... - PurityImmunogen affinity purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab51523 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| IHC-Fr | IHC-Fr: Use at an assay dependent concentration. |
| WB | WB: Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa). |
Target
- RelevanceSLIRP is a RNA binding protein that acts as a nuclear receptor corepressor. It may act by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. SLIRP binds the STR7 loop of SRA RNA. It is also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. It contains 1 RRM (RNA recognition motif) domain. SLIRP is predominantly founs in mitochondrial with a limited role in the nucleus where it is recruited to nuclear receptor target promoters.
- Cellular localizationMitochondrial and Nuclear; Predominantly mitochondrial.
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Database links
- Entrez Gene: 81892 Human
- Omim: 610211 Human
- SwissProt: Q9GZT3 Human
- Unigene: 655105 Human
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Alternative names
- C14orf156 antibodyChromosome 14 open reading frame 156 antibodyDC50 antibody
- PD04872 antibodySLIRP antibodySRA stem loop interacting RNA binding protein, mitochondrial antibody
see all
Anti-SLIRP antibody images
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Western blot - SLIRP antibody (ab51523)Anti-SLIRP antibody (ab51523) at 0.6 µg/ml + human liver lysate
Predicted band size : 12 kDa
Observed band size : 12 kDa
References for Anti-SLIRP antibody (ab51523)
This product has been referenced in:
- Bayat V et al. Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans. PLoS Biol 10:e1001288 (2012). WB ; Human . Read more (PubMed: 22448145) »
- Ebmeier CC & Taatjes DJ Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A 107:11283-8 (2010). WB ; Human . Read more (PubMed: 20534441) »
