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Anti-SLIRP antibody (ab51523)

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Overview

Product name

Anti-SLIRP antibody
See all SLIRP products (2) ...

Description

Rabbit polyclonal to SLIRP

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Does not react with

Mouse

Immunogen

Synthetic peptide made to a C terminal region of human SLIRP.

Positive control

Human liver lysate

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: Tris glycine, 150mM Sodium chloride

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> Nuclear Hormone Receptors >> Co-activators/co-repressors

  • Western blot - SLIRP antibody (ab51523)Western blot - SLIRP antibody (ab51523) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab51523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa).

Target

Relevance

SLIRP is a RNA binding protein that acts as a nuclear receptor corepressor. It may act by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. SLIRP binds the STR7 loop of SRA RNA. It is also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. It contains 1 RRM (RNA recognition motif) domain. SLIRP is predominantly founs in mitochondrial with a limited role in the nucleus where it is recruited to nuclear receptor target promoters.

Cellular localization

Mitochondrial and Nuclear; Predominantly mitochondrial.

Alternative names

  • C14orf156 antibody
  • Chromosome 14 open reading frame 156 antibody
  • DC50 antibody
  • PD04872 antibody
  • SLIRP antibody
  • SRA stem loop interacting RNA binding protein, mitochondrial antibody
see all

Database links

Anti-SLIRP antibody images:

  Western blot - SLIRP antibody (ab51523)

Western blot - SLIRP antibody (ab51523)

Anti-SLIRP antibody (ab51523) at 0.6 µg/ml + human liver lysate

Predicted band size : 12 kDa
Observed band size : 12 kDa

References for Anti-SLIRP antibody (ab51523)

This product has been referenced in:

  • Bayat V  et al. Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans. PLoS Biol 10:e1001288 (2012). WB; Human.Read more (PubMed: 22448145) »
  • Ebmeier CC & Taatjes DJ Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A 107:11283-8 (2010). WB; Human.Read more (PubMed: 20534441) »

See all 4 publications for this product

Publishing research using ab51523? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"