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Read our guarantee »Overview
Product name
SNX5 protein (T7 Tag)
Protein description
Recombinant full length SNX5 protein (Human) fused to T7-Tag at N-terminal end.
Expression host
E. coli
Properties
Purity
> 95% by SDS-PAGE
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.002% Sodium Azide
Constituents: 10mM Tris, 0.1% Triton X-100, pH 8
Concentration
Concentration information loading...
Research areas
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
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SDS-PAGE - SNX5 protein (ab40262)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab40262 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
MS
- 1 Image
SDS-PAGE
Application notes
MS: Use at an assay dependent dilution.
SDS-PAGE: Use at an assay dependent dilution.
This protein can be used with studies using ab5983.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.
Sequence similarities
Belongs to the sorting nexin family.
Contains 1 BAR domain.
Contains 1 PX (phox homology) domain.
Domain
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate.
Cellular localization
Early endosome membrane. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm. Cell projection > phagocytic cup. Cell projection > ruffle. Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation.
Target information above from: UniProt accessionQ9Y5X3
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
SNX5 protein (T7 Tag) images:
SDS-PAGE - SNX5 protein (ab40262)
Analysis of SNX5 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining shows a band around 47kDa.
References for SNX5 protein (T7 Tag) (ab40262)
ab40262 has not yet been referenced specifically in any publications.
Publishing research using ab40262? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"