Anti-SOD2 antibody [23G5] (ab16954)

Overview

• Product nameAnti-SOD2 antibody [23G5]See all SOD2 primary antibodies ...
• Description
  Mouse monoclonal [23G5] to SOD2
• SpecificityWe have data to indicate that this antibody may not cross react with Mouse. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
• Tested applicationsWB, IP more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Recombinant full length protein (Human).

• Positive controlHeLa whole cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 50% Glycerol, PBS
• Concentration information loading...
• PurityIgG fraction
• Clonality Monoclonal
• Clone number23G5
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Apoptosis

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Antioxidants

  • Cancer
  • Cancer Metabolism
  • Cellular metabolic process

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Cardiovascular
  • Vasculature
  • Endothelium

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Other

  • Cell Biology
  • Apoptosis
  • Mitochondrial

Applications

Target

• FunctionDestroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
• Involvement in diseaseGenetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
• Sequence similaritiesBelongs to the iron/manganese superoxide dismutase family.
• Post-translational
  modificationsNitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
• Cellular localizationMitochondrion matrix.

Target information above from: UniProt accession P04179 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 6648 Human
  • Entrez Gene: 20656 Mouse
  • Entrez Gene: 24787 Rat
  • Omim: 147460 Human
  • SwissProt: P04179 Human
  • SwissProt: P09671 Mouse
  • SwissProt: P07895 Rat
  • Unigene: 487046 Human

  • Unigene: 290876 Mouse
  • Unigene: 10488 Rat

  see all

• Alternative names
  Indophenoloxidase B antibodyIPO B antibodyIPO-B antibody

  IPOB antibodymanganese containing superoxide dismutase antibodymanganese SOD antibodyManganese superoxide dismutase antibodyMangano superoxide dismutase antibodyMn SOD antibodyMn superoxide dismutase antibodyMNSOD antibodyMVCD6 antibodySOD 2 antibodySOD2 antibodySODM_HUMAN antibodySuperoxide dismutase [Mn] mitochondrial antibodySuperoxide dismutase [Mn], mitochondrial antibodySuperoxide dismutase 2 mitochondrial antibody

  see all