Anti-SOX17 antibody (ab83258)
- Product nameAnti-SOX17 antibodySee all SOX17 primary antibodies ...
- DescriptionRabbit polyclonal to SOX17
- Tested applicationsWB, ELISA more details
- Species reactivityReacts with: Human
Predicted to work with: Mouse, Dog
Synthetic peptide corresponding to a region within internal sequence amino acids 360-409 (RTEFEQYLHF VCKPEMGLPY QGHDSGVNLP DSHGAISSVV SDASSAVYYC) of human SOX17 (NP_071899).
- Positive controlHeLa cell lysate.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: 2% Sucrose, PBS
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesPurified by peptide affinity chromatography method.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab83258 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionActs as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.
- Tissue specificityExpressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
- Involvement in diseaseDefects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3) [MIM:613674]. VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
- Sequence similaritiesContains 1 HMG box DNA-binding domain.
Contains 1 Sox C-terminal domain.
- Cellular localizationNucleus.
- FLJ22252 antibodySOX17 antibodySOX17_HUMAN antibody
- SRY (sex determining region Y) box 17 antibodySRY box 17 antibodySRY related HMG box transcription factor SOX17 antibodyTranscription factor SOX-17 antibodyTranscription factor SOX17 antibodyVUR3 antibody
Anti-SOX17 antibody images
Anti-SOX17 antibody (ab83258) at 1 µg/ml (in 5% skim milk / PBS buffer) + HeLa cell lysate at 10 µg
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 44 kDa
Observed band size : 44 kDa
Additional bands at : 92 kDa. We are unsure as to the identity of these extra bands.
References for Anti-SOX17 antibody (ab83258)
ab83258 has not yet been referenced specifically in any publications.