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- Secondary antibodies
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Product name
Anti-SOX4 antibody
See all SOX4 products (8) ...
Description
Rabbit polyclonal to SOX4
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide corresponding to internal region of human SOX4.
Epitope
Internal region.
Positive control
Human brain tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4
Concentration
Concentration information loading...
Purification notes
ab52043 is affinity purified.
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Neural Stem Cells >> Intracellular
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HMG Box
Neuroscience >> Neurology process >> Neural Signal Transduction
Neuroscience >> Cell Type Marker >> Neural Stem Cell marker
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SOX4 antibody (ab52043)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab52043 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Target
Relevance
The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate. SOX4 shows a high degree of sequence homology with SOX11. Both are expressed in the CNS. SOX4 and SOX11 expression increase together in the developing CNS (with some exceptions: external granule layer of the cerebellum). SOX4 knock-out mice have been shown to die of a heart defect half way through gestation with no observable CNS phenotype, although it has been proposed that SOX11 compensates for the absence of SOX4.
Cellular localization
Nuclear
Alternative names
- Ecotropic viral integration site 16 antibody
- EVI 16 antibody
- EVI16 antibody
see all
Database links
- Entrez Gene: 6659 Human
- Omim: 184430 Human
- SwissProt: Q06945 Human
- Unigene: 643910 Human
Anti-SOX4 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SOX4 antibody (ab52043)
ab52043, at dilution of 1/50, staining SOX4 in formalin fixed paraffin embedded human brain tissue by Immunohistochemistry.
References for Anti-SOX4 antibody (ab52043)
This product has been referenced in:
- Melcher R et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis 32:636-42 (2011). IHC-P; Human.Read more (PubMed: 21297112) »
- Pece S et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140:62-73 (2010). IHC-P; Mouse.Read more (PubMed: 20074520) »
See all 4 publications for this product
Publishing research using ab52043? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"