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Product name
SP600125
Description
JNK inhibitor
Biological description
Potent and selective JNK1, -2, and -3 inhibitor (IC50=0.11 μM). SP600125 is a reversible ATP competitive inhibitor with >20 fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
1,9-Pyrazoloanthrone
Molecular Weight
220.23
Chemical structure
Molecular formula
C14H8N2O
CAS Number
129-56-6
Solubility
Soluble in DMSO to 100 mM and in ethanol to 10 mM (with heating)
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> JNK >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for SP600125 (ab120065)
This product has been referenced in:
- Guan QH et al. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain Res 1092:36-46 (2006).Read more (PubMed: 16674927) »
- Heo YS et al. Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125. EMBO J 23:2185-95 (2004).Read more (PubMed: 15141161) »
See all 4 publications for this product
Publishing research using ab120065? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"