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Products:Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Overview
Product name
SPEN peptide (1503-1517)
Protein description
Synthetic peptide: C-DSEGKMDDKKEDHKE, corresponding to Internal sequence amino acids 1503-1517 of Human SPEN
This Peptide was used as an immunogen for ab45865 - SPEN antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Concentration
Concentration information loading...
Sequence
C-DSEGKMDD KKEDHKE
Protein info
Relevance
SPEN is an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. It is a negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. SPEN blocks the differentiation of precursor B-cells into marginal zone B-cells. It probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. SPEN may bind both to DNA and RNA.
Cellular localization
Nuclear. Associates with chromatin.
References for SPEN peptide (1503-1517) (ab45877)
ab45877 has not yet been referenced specifically in any publications.
Publishing research using ab45877? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"