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Anti-ST14 antibody - Aminoterminal end cleaved protein (ab28265)

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1 question for ab28265

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Question 1

Wednesday 30-May-2007

I'm working with matriptase (ST14) and I want to identify/characterize forms that I see on SDS-PAGE. Your antibodies directed against different domains of matriptase could be of great use for me but I need to know the sequence that the antibody is directed against. Is it possible to have it?? You have one antibody against the stem region and one against amino end cleaved that i'm interested in. Thank you very much.

ANSWER:

  

Thank you for your enquiry.

I am sorry but after enquiring at the originator of the product, it appears that the exact amino acid sequence information is proprietary. I sincerely apologize for any inconvenience caused.

However, I can confirm that the latent matriptase contains a transmembrane motif (amino acids 56 - 76) and has a cytoplasmic tail (first 55 amino acids). The extracellular domains contain a stem region (aa 77 - 213), followed by two CUB domains (CUB 1 is aa 214 - 334) and four repeats of LDL-receptor-like homology, and a serine protease domain located in the carboxyterminal end of the protein. The epitope for RP2-Matriptase-1 falls within the first half of the stem region, and the epitope for RP4-Matriptase ends just before the start of the first CUB domain.

Should you have any other questions, please do not hesitate to contact me.

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