ST14 peptide (Catalytic domain) (ab41264)

Product Name 

ST14 peptide (Catalytic domain)

Product type 

Proteins and Peptides

Peptide 

Synthetic peptide ST14.


This peptide was used as an immunogen for ab28266 - ST14 antibody - Catalytic domain.

Specificity 

We have a range of domain specific antibodies for this target. For a full list please see all ST14 antibodies

Tested applications 
(see key)

ELISA, WB

Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28266. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Matriptase
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Other Enzymes

Relevance 

ST14 degrades extracellular matrix. It is proposed to play a role in breast cancer invasion and metastasis. ST14 was first identified as a gelatinolytic proteinase in the media and cell lysates of breast tumor cells in culture. Originally it was thought to be specific for either prostate tumors or breast tumors, or to be a tumor suppressor. More extensive characterizations determined that ST14 is found in many normal and tumor cell lines, and in breast milk, serum and urine. ST14 is a Type II serine proteinase, meaning it contains a transmembrane motif in the amino end of the protein. The latent protein is membrane attached, and has a cytoplasmic tail. The extracellular domains contain a stem region, followed by two CUB domains and four repeats of LDL receptor like homology, and a serine protease domain located in the carboxyterminal end of the protein. ST14 is a member of the S1A family of the PA clan of serine proteinases, which includes acrosin, kallikreins, trypsin, chymotrypsin, and many other important enzymes.

Purity 

>95% by SDS-PAGE

Storage buffer 

Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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