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Product Name
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ST14 peptide (Cytoplasmic domain)
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Product type
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Proteins and Peptides
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Peptide
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This peptide was used as an immunogen for ab28268 - ST14 antibody - Cytoplasmic domain.
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Specificity
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We have a range of domain specific antibodies for this target. For a full list please see all ST14 antibodies
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Tested applications
(see key)
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ELISA, WB
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28268. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Matriptase
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Other Enzymes
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Relevance
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ST14 degrades extracellular matrix. It is proposed to play a role in breast cancer invasion and metastasis. ST14 was first identified as a gelatinolytic proteinase in the media and cell lysates of breast tumor cells in culture. Originally it was thought to be specific for either prostate tumors or breast tumors, or to be a tumor suppressor. More extensive characterizations determined that ST14 is found in many normal and tumor cell lines, and in breast milk, serum and urine. ST14 is a Type II serine proteinase, meaning it contains a transmembrane motif in the amino end of the protein. The latent protein is membrane attached, and has a cytoplasmic tail. The extracellular domains contain a stem region, followed by two CUB domains and four repeats of LDL receptor like homology, and a serine protease domain located in the carboxyterminal end of the protein. ST14 is a member of the S1A family of the PA clan of serine proteinases, which includes acrosin, kallikreins, trypsin, chymotrypsin, and many other important enzymes.
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ST14 peptide (Cytoplasmic domain) (ab41262) |
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ST14 peptide (Cytoplasmic domain) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to ST14
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ST14 peptide (Cytoplasmic domain) - more information
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