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- Secondary antibodies
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Product name
Anti-ST2 antibody
See all ST2 products (4) ...
Description
Rabbit polyclonal to ST2
Specificity
ab25877 reacts all three known ST2 isoforms.
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Synthetic peptide corresponding to 16 amino acids at the amino terminus of Mouse ST2.
Positive control
Mouse kidney cell lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Cardiovascular >> Heart >> Hypertrophy >> Other
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Cardiovascular >> Angiogenesis >> Cytokines >> Interleukin
Applications
Show applications key
Our Abpromise guarantee covers the use of ab25877 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 2 µg/ml.
WB: Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 40 kDa.
Target
Relevance
ST2 is a member of a superfamily containing the Interleukin 1 (IL1) receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL1 receptor and Toll-like receptor 4 (TLR4) signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.
Cellular localization
Type I membrane protein. Isoform B is secreted. Isoform C localizes on the plasma membrane.
Alternative names
- DER-4 antibody
- DER4 antibody
- homolog of mouse growth stimulation-expressed antibody
see all
Database links
- Entrez Gene: 17082 Mouse
- SwissProt: P14719 Mouse
Anti-ST2 antibody images:
Western blot - ST2 antibody (ab25877)
All lanes : Anti-ST2 antibody (ab25877) at 1 µg/ml
Lane 1 : Mouse kidney lysate in presence of blocking peptide (1ug/ml)
Lane 2 : Mouse kidney lysate in absence of blocking peptide
Predicted band size : 40 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ST2 antibody (ab25877)
ab25877 at 2µg/ml staining ST2 in mouse kidney tissue by IHC
References for Anti-ST2 antibody (ab25877)
This product has been referenced in:
- Cho KA et al. IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice. Am J Physiol Lung Cell Mol Physiol 302:L429-40 (2012). WB; Mouse.Read more (PubMed: 22180658) »
- Westcott DJ et al. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med 206:3143-56 (2009). IHC (PFA fixed); Mouse.Read more (PubMed: 19995956) »
See all 3 publications for this product
Publishing research using ab25877? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"