RabMAb

Anti-STAT2 antibody [Y141] (ab32367)

Overview

  • Product nameAnti-STAT2 antibody [Y141]
    See all STAT2 primary antibodies
  • Description
    Rabbit monoclonal [Y141] to STAT2
  • SpecificityThis antibody detects both long and short forms of STAT2.
  • Tested applicationsWB, ICC, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues near N-terminus of human Stat-2.

  • Positive control
    • K562 cell lysate and human thyroid cancer
  • General notesProduced under U.S. Patent No. 5,675,063.

Properties

Applications

Our Abpromise guarantee covers the use of ab32367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/10000. Detects a band of approximately 98 kDa (predicted molecular weight: 98 kDa).
ICC 1/50 - 1/100.
IHC-P 1/100 - 1/250.
  • Application notesIs unsuitable for Flow Cyt or IP.
  • Target

    • FunctionSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
    • Sequence similaritiesBelongs to the transcription factor STAT family.
      Contains 1 SH2 domain.
    • Post-translational
      modifications
      Tyrosine phosphorylated in response to IFN-alpha.
    • Cellular localizationCytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
    • Information by UniProt
    • Database links
    • Alternative names
      • Homo sapiens interferon alpha induced transcriptional activator antibody
      • Homo sapiens interferon alpha induced transcriptional activator antibody
      • interferon alpha induced transcriptional activator antibody
      • interferon alpha induced transcriptional activator antibody
      • ISGF 3 antibody
      • ISGF3 antibody
      • MGC59816 antibody
      • P113 antibody
      • P113 antibody
      • signal transducer and activator of transcription 2 113kD antibody
      • signal transducer and activator of transcription 2 113kD antibody
      • Signal transducer and activator of transcription 2 antibody
      • STAT113 antibody
      • STAT113 antibody
      • Stat2 antibody
      • STAT2_HUMAN antibody
      see all

    Anti-STAT2 antibody [Y141] images

    • Anti-STAT2 antibody [Y141] (ab32367) at 1/500 dilution + K562 cell lysate

      Predicted band size : 98 kDa
      Observed band size : 100 kDa (why is the actual band size different from the predicted?)
    • Immunohistochemical analysis of paraffin-embedded human thyroid cancer using ab32367

    References for Anti-STAT2 antibody [Y141] (ab32367)

    ab32367 has not yet been referenced specifically in any publications.

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