Anti-STAT2 antibody [Y141] (ab32367)

Overview

• Product nameAnti-STAT2 antibody [Y141]See all STAT2 primary antibodies ...
• Description
  Rabbit monoclonal [Y141] to STAT2
• SpecificityThis antibody detects both long and short forms of STAT2.
• Tested applicationsWB, ICC, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  A synthetic peptide corresponding to residues near N-terminus of human Stat-2.

• Positive controlK562 cell lysate and human thyroid cancer
• General notesProduced under U.S. Patent No. 5,675,063.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• PurityIgG fraction
• Clonality Monoclonal
• Clone numberY141
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • STATs

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • STATs

Applications

Target

• FunctionSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
• Sequence similaritiesBelongs to the transcription factor STAT family.
  Contains 1 SH2 domain.
• Post-translational
  modificationsTyrosine phosphorylated in response to IFN-alpha.
• Cellular localizationCytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

Target information above from: UniProt accession P52630 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 6773 Human
  • Entrez Gene: 20847 Mouse
  • Entrez Gene: 288774 Rat
  • Omim: 600556 Human
  • SwissProt: P52630 Human
  • SwissProt: Q9WVL2 Mouse
  • Unigene: 530595 Human
  • Unigene: 293120 Mouse

  • Unigene: 471333 Mouse
  • Unigene: 24237 Rat

  see all

• Alternative names
  Homo sapiens interferon alpha induced transcriptional activator antibodyHomo sapiens interferon alpha induced transcriptional activator antibodyinterferon alpha induced transcriptional activator antibody

  interferon alpha induced transcriptional activator antibodyISGF3 antibodyMGC59816 antibodyP113 antibodyP113 antibodysignal transducer and activator of transcription 2 113kD antibodysignal transducer and activator of transcription 2 113kD antibodySignal transducer and activator of transcription 2 antibodySTAT113 antibodySTAT113 antibodyStat2 antibodySTAT2_HUMAN antibody

  see all

Anti-STAT2 antibody [Y141] images

• 

  Western blot - STAT2 antibody [Y141] (ab32367)
  Anti-STAT2 antibody [Y141] (ab32367) at 1/500 dilution + K562 cell lysate
  
  Predicted band size : 98 kDa
  Observed band size : 100 kDa (why is the actual band size different from the predicted?)
  
• 

  Immunohistochemistry (Paraffin-embedded sections) - STAT2 antibody [Y141] (ab32367)
  Immunohistochemical analysis of paraffin-embedded human thyroid cancer using ab32367