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Anti-STAT5b antibody (ab45290)

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Overview

Product name

Anti-STAT5b antibody
See all STAT5b products (12) ...

Description

Rabbit polyclonal to STAT5b

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Synthetic STAT5b peptide (Human)

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Response to hypoxia
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> STATs
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> STATs

Applications

Show applications key

Our Abpromise guarantee covers the use of ab45290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

Application notes

WB: 1/1000. Detects a band of approximately 96 kDa (In mouse, this protein is truncated and displays as an 80kDa band).

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Involvement in disease

Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.

Sequence similarities

Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

Cellular localization

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Target information above from: UniProt accessionP51692 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Transcription factor STAT5B antibody
  • Signal transducer and activator of transcription 5B antibody
  • STA5B_HUMAN antibody
  • STAT5 antibody
  • Stat5b antibody
see all

Database links

References for Anti-STAT5b antibody (ab45290)

ab45290 has not yet been referenced specifically in any publications.

Publishing research using ab45290? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"