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Anti-STAT5b antibody (ab65743)

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Overview

Product name

Anti-STAT5b antibody
See all STAT5b products (12) ...

Description

Sheep polyclonal to STAT5b

Tested applications

IPmore details

Cross reactivity

Reacts with

Mouse, Human

Predicted to work with

Rat, Chicken, Cow, Pig, Xenopus laevis, Cynomolgus Monkey

Immunogen

Synthetic peptide: CMDSQWIPHAQS, corresponding to C terminal amino acids 777-787 of Human STAT5b conjugated to KLH

CMDSQWIPHA QS

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

Rat liver lysate.

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 150mM Sodium chloride, 10mM HEPES, pH 7.5

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Response to hypoxia
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> STATs
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> STATs

  • Immunoprecipitation - STAT5b antibody (ab65743)Immunoprecipitation - STAT5b antibody (ab65743) image (enlarge)

Applications

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Our Abpromise guarantee covers the use of ab65743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Involvement in disease

Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.

Sequence similarities

Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

Cellular localization

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Target information above from: UniProt accessionP51692 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Transcription factor STAT5B antibody
  • Signal transducer and activator of transcription 5B antibody
  • STA5B_HUMAN antibody
  • STAT5 antibody
  • Stat5b antibody
see all

Database links

see all

Anti-STAT5b antibody images:

  Immunoprecipitation - STAT5b antibody (ab65743)

Immunoprecipitation - STAT5b antibody (ab65743)

Immunoprecipitation of ab65743 (2µg/mg lysate) with rat liver lysate using protein G beads (lane 1), and controls using beads alone (lane 2). Western blot analysis by another commercially available STAT5b antibody.

References for Anti-STAT5b antibody (ab65743)

This product has been referenced in:

  • Elliott Set al. Lack of expression and function of erythropoietin receptors in the kidney. Nephrol Dial Transplant : (2011). IP; Human.Read more (PubMed: 22167585) »

See 1 publication for this product

Publishing research using ab65743? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"