Anti-STEAP3 antibody (ab126068)
Key features and details
- Rabbit polyclonal to STEAP3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-STEAP3 antibody
See all STEAP3 primary antibodies -
Description
Rabbit polyclonal to STEAP3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 1-218 of Human STEAP3 (Q658P3).
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Positive control
- HepG2 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126068 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 54 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 54 kDa. |
Target
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Function
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. -
Tissue specificity
Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. -
Involvement in disease
Anemia, hypochromic microcytic, with iron overload 2 -
Sequence similarities
Belongs to the STEAP family.
Contains 1 ferric oxidoreductase domain. -
Post-translational
modificationsProteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.
Glycosylated. -
Cellular localization
Endosome membrane. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. - Information by UniProt
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Database links
- Entrez Gene: 55240 Human
- Entrez Gene: 68428 Mouse
- Entrez Gene: 170824 Rat
- Omim: 609671 Human
- SwissProt: Q658P3 Human
- SwissProt: Q8CI59 Mouse
- SwissProt: Q5RKL5 Rat
- Unigene: 647822 Human
see all -
Alternative names
- 1010001D01Rik antibody
- Dudlin 2 antibody
- Dudlin2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab126068 has not yet been referenced specifically in any publications.