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Overview

  • Product nameAnti-SUN1 antibodySee all SUN1 primary antibodies ...
  • Description
    Mouse polyclonal to SUN1
  • SpecificityThis antibody is reactive against mammalian transfected lysate.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    SUN1 (AAH13613, 1 a.a. ~ 258 a.a) full-length human protein.

  • Positive controlSUN1 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/1000. Detects a band of approximately 35 kDa (predicted molecular weight: 90 kDa).

Target

  • FunctionComponent of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs).
  • Sequence similaritiesContains 1 SUN domain.
  • DomainThe SUN domain may play a role in the nuclear anchoring and/or migration.
  • Cellular localizationNucleus inner membrane.

    • Target information above from: UniProt accession O94901 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Protein unc-84 homolog A antibodySad1/unc 84 protein like 1 antibodySad1/unc-84 protein-like 1 antibody
        Sun domain-containing protein 1 antibodySun1 antibodySUN1_HUMAN antibodyUNC 84 homolog A (C elegans) antibodyUNC 84A antibodyUNC84 A antibodyUNC84 antibodyUNC84 homolog A (C elegans) antibodyUNC84A antibody
      see all

    Anti-SUN1 antibody images

    • Western blot - SUN1 antibody (ab67999)
      Western blot - SUN1 antibody (ab67999)
      All lanes : Anti-SUN1 antibody (ab67999) at 1/500 dilution

      Lane 1 : SUN1 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 90 kDa
      Observed band size : 35 kDa (why is the actual band size different from the predicted?)

    References for Anti-SUN1 antibody (ab67999)

    ab67999 has not yet been referenced specifically in any publications.

    Publishing research using ab67999 ? Please let us know so that we can cite the reference in this datasheet

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