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Product Name
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SV40 T-antigen antibody [LP7N]
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See all SV40 T-antigen antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [LP7N] to SV40 T-antigen
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Immunogen
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Detergent insoluble fraction of SVK14 cell line (SV40 transformed neonatal keratinocytes).
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Reacts with
(species key)
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SV40
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Epitope
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Epitope has been mapped to a region of the SV40 T antigen which is not covered by small t-shared domain or ND2 protein, since both are negative. Epitope is denaturation-sensitive and does not immunoblot.
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Tested applications
(see key)
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IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Cancer >> Oncoproteins/suppressors >> Viral proteins >> SV40 antigen
Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Other dsDNA viruses
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Relevance
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SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.
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SV40 T-antigen antibody [LP7N] (ab43234) |
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 1489531 (Simian Virus 40 (SV40))
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| SwissProt | | P03070 (Simian Virus 40 (SV40))
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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LP7N
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Isotype
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IgG1
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Purity
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IgG fraction
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Storage buffer
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Preservative: None
Constituents: PBS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this SV40 T-antigen antibody [LP7N] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to SV40 T-antigen
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SV40 T-antigen antibody [LP7N] - more information
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Customer FAQs regarding SV40 T-antigen antibody [LP7N] |
Protocols for SV40 T-antigen antibody [LP7N] |
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