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Anti-SV40 T-antigen antibody [LP7N] (ab43234)

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Overview

Product name

Anti-SV40 T-antigen antibody [LP7N]
See all SV40 T-antigen products (6) ...

Description

Mouse monoclonal [LP7N] to SV40 T-antigen

Tested applications

IHC-Frmore details

Cross reactivity

Reacts with

Simian Virus 40 (SV40)

Immunogen

Detergent insoluble fraction of SVK14 cell line (SV40 transformed neonatal keratinocytes).

Epitope

Epitope has been mapped to a region of the SV40 T antigen which is not covered by small t-shared domain or ND2 protein, since both are negative. Epitope is denaturation-sensitive and does not immunoblot.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

LP7N

Isotype

IgG1

Research areas

Cancer >> Oncoproteins/suppressors >> Viral proteins >> SV40 antigen
Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Other dsDNA viruses

Applications

Show applications key

Our Abpromise guarantee covers the use of ab43234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.

Cellular localization

Nuclear

Alternative names

  • Large T antigen antibody
  • LT AG antibody
  • LT antibody
  • LTAG antibody
  • Small T antigen antibody
see all

Database links

References for Anti-SV40 T-antigen antibody [LP7N] (ab43234)

ab43234 has not yet been referenced specifically in any publications.

Publishing research using ab43234? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"