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Products:Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Other dsDNA viruses
Overview
Product name
Anti-SV40 T-antigen antibody [PAb419]
See all SV40 T-antigen products (6) ...
Description
Mouse monoclonal [PAb419] to SV40 T-antigen
Tested applications
ICC/IF, IPmore details
Cross reactivity
SV40 infected cells.
Immunogen
Full length protein (SV40).
Epitope
The N-terminal domain of the large and small T-antigen.
Positive control
SV80 or SV-T2 cells.
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 0.2% Gelatin, 0.05M Sodium phosphate
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Monoclonal
Clone number
PAb419
Myeloma
NS1
Isotype
IgG2a
Light chain type
kappa
Research areas
Cancer >> Oncoproteins/suppressors >> Viral proteins >> SV40 antigen
Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Other dsDNA viruses
Applications
Show applications key
Our Abpromise guarantee covers the use of ab16848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use a concentration of 1 - 5 µg/ml.
IP: Use a concentration of 1 - 2 µg/ml.
Target
Relevance
SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.
Cellular localization
Nuclear
Alternative names
- Large T antigen antibody
- LT AG antibody
- LT antibody
see all
References for Anti-SV40 T-antigen antibody [PAb419] (ab16848)
This product has been referenced in:
- McLaughlin-Drubin MEet al. The Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6. J Virol : (2008).Read more (PubMed: 18579589) »
See 1 publication for this product
Publishing research using ab16848? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"