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Product Name
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SV40 T-antigen antibody [Pab 416]
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See all SV40 T-antigen antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [Pab 416] to SV40 T-antigen
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Immunogen
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SV40 transformed mouse cells.
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Reacts with
(species key)
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SV40
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 82 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Cancer >> Oncoproteins/suppressors >> Viral proteins >> SV40 antigen
Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Other dsDNA viruses
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Relevance
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SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 1489531 (Simian Virus 40 (SV40))
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| SwissProt | | P03070 (Simian Virus 40 (SV40))
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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Pab 416
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Myeloma
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P3-NS1/1-Ag4-1
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Isotype
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IgG2a
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Purity
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IgG fraction
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Storage buffer
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Preservative: None
Constituents: PBS
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Form
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Liquid
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Concentration
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1.200 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this SV40 T-antigen antibody [Pab 416] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for SV40 T-antigen antibody [Pab 416] (ab20248)
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This product has been used in:
Harlow E et al. Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol 39:861-9 (1981). PubMed: 6169844
If you publish research using ab20248 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to SV40 T-antigen
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