Anti-Scavenger Receptor BI + BII antibody (ab36970)
Key features and details
- Rabbit polyclonal to Scavenger Receptor BI + BII
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
-
Product name
Anti-Scavenger Receptor BI + BII antibody -
Description
Rabbit polyclonal to Scavenger Receptor BI + BII -
Host species
Rabbit -
Specificity
ab36970 is specific for SR-BI and SR-BII. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat -
Immunogen
Synthetic peptide, corresponding to extracellular amino acids 230-280 of Scavenger Receptor BI + BII
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: Whole serum -
Concentration information loading...
-
Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab36970 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/1000. Predicted molecular weight: 82 kDa.
|
Notes |
---|
WB
1/1000. Predicted molecular weight: 82 kDa. |
Target
-
Relevance
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells. -
Cellular localization
Lysosome; lysosomal membrane; multi-pass membrane protein. -
Database links
- Entrez Gene: 12492 Mouse
- Entrez Gene: 20778 Mouse
- Entrez Gene: 117106 Rat
- Entrez Gene: 25073 Rat
- SwissProt: O35114 Mouse
- SwissProt: Q61009 Mouse
- SwissProt: P27615 Rat
- SwissProt: P97943 Rat
-
Alternative names
- CD36 and LIMPII Analogous 1 antibody
- CD36L1 antibody
- CD36L2 antibody
see all
Images
Datasheets and documents
-
Datasheet download
References (4)
ab36970 has been referenced in 4 publications.
- Radulovic S et al. Endothelial lipase increases eNOS activating capacity of high-density lipoprotein. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158612 (2020). PubMed: 31923467
- Balasubramanian K et al. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci Signal 8:ra95 (2015). PubMed: 26396268
- Badeau RM et al. Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters. J Steroid Biochem Mol Biol 116:44-9 (2009). Blocking ; Human . PubMed: 19406243
- Acín S et al. Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice. J Biochem (Tokyo) 140:383-91 (2006). PubMed: 16873395