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Products:Neuroscience >> Neurology process >> Growth and Development >> Axonal Guidance Proteins
Overview
Product name
Semaphorin 3A peptide
See all Semaphorin 3A products (5) ...
Protein description
Synthetic peptide corresponding to amino acids in the central region of human Sema3A.
Properties
Biological activity
The ab42768 peptide blocks antibodies that recognise amino acids in the central region of human Sema3A. This sequence is highly conserved in rat and mouse Sema3A, and has low homology to other semaphorin family members.
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Research areas
Cardiovascular >> Heart >> Hypertrophy >> Other
Cardiovascular >> Heart >> Cardiogenesis >> Transcription factors/regulators
Cardiovascular >> Heart >> Cardiac arrhythmias
Neuroscience >> Neurology process >> Growth and Development >> Axonal Guidance Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab42768 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
ELISA
Application notes
BL: Use at a concentration of 1 µg/ml. Recommended for blocking antibody reactivity in Western Blot and Immunocytochemistry.
ELISA: 10-100ng/well, established in 96-well Nunc immunoplates where peptide was bound to plates for 2hrs in 0.1M sodium carbonate buffer, pH 8.5.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Relevance
One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co receptors, Neuropilin 1 and Plexin A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A containing region. Thus, Sema3A and its co receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.
Cellular localization
Plasma membrane and Secreted
References for Semaphorin 3A peptide (ab42768)
ab42768 has not yet been referenced specifically in any publications.
Publishing research using ab42768? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"