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Anti-Serine Palmitoyltransferase antibody - C-terminal (ab71631)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab71631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: 1/1000.
WB WB: 1/100 - 1/500. Detects a band of approximately 62 kDa (predicted molecular weight: 62 kDa).

Target

  • FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate.
  • Tissue specificityWidely expressed.
  • PathwayLipid metabolism; sphingolipid metabolism.
  • Involvement in diseaseDefects in SPTLC2 are the cause of hereditary sensory and autonomic neuropathy type 1C (HSAN1C) [MIM:613640]. It is a form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibration in the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory loss with ulceration and osteomyelitis, and distal muscle weakness.
  • Sequence similaritiesBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  • Cellular localizationEndoplasmic reticulum membrane.

    • Target information above from: UniProt accession O15270 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      KIAA0526 antibodyLCB 2 antibodyLCB2 antibody
      LCB2a antibodyLong chain base biosynthesis protein 2 antibodyLong chain base biosynthesis protein 2a antibodySerine palmitoyl CoA transferase 2 antibodySerine palmitoyltransferase 2 antibodySerine palmitoyltransferase long chain base subunit 2 antibodySerine palmitoyltransferase subunit II antibodySerine-palmitoyl-CoA transferase 2 antibodySPT 2 antibodySPT2 antibodySPTC2_HUMAN antibodySPTLC 2 antibodySPTLC2 antibody
    see all

Anti-Serine Palmitoyltransferase antibody - C-terminal images

  • Western blot - Serine Palmitoyltransferase antibody - C-terminal (ab71631)
    Western blot - Serine Palmitoyltransferase antibody - C-terminal (ab71631)
    Anti-Serine Palmitoyltransferase antibody - C-terminal (ab71631) at 1/100 dilution + mouse liver tissue lysate at 12.5 µg

    Predicted band size : 62 kDa
    Observed band size : 62 kDa
    Additional bands at : 75 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Serine Palmitoyltransferase antibody - C-terminal (ab71631)

ab71631 has not yet been referenced specifically in any publications.

Publishing research using ab71631 ? Please let us know so that we can cite the reference in this datasheet

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Kindly advise the immunogen's sequence of ab71631.

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Here is the requested information:

Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 532-562 of Human Serine Palmitoyltransferase

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