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Products:Neuroscience >> Neurotransmitter >> Biogenic Amines >> Serotonin / 5HT
Overview
Product name
Anti-Serotonin antibody
See all Serotonin products (9) ...
Description
Rabbit polyclonal to Serotonin
Specificity
Using a conjugate 5-hydroxytryptamine-Glutaraldehyde-Protein, antibody specificity was performed with an ELISA test by competition experiments with the following compounds: (Compound = Cross-Reactivity Ratio §) 5-Hydroxytryptamine-G-PL = 1 5-Hydroxytryptamine=G=PL¥ = 1/10 5-Methoxytryptamine-G-PL = 1/25 Tryptamine-G-PL = 1/51 5-Hydroxytryptophan-G-PL = 1/175 5-Hydroxytryptamine = 1/1,150 Tryptophan-G-PL = 1/3,400 5-Methoxytryptophan-G-PL = 1/19,800 G = Glutaraldehyde, PL = poly-Lysine § 5-Hydroxytryptamine-G-PL concentration/unconjugated or conjugated indolealkylamine concentration at halfdisplacement. ¥ Non-reduced conjugate
Tested applications
ELISA, ICC, IHC-Fr, WBmore details
Immunogen
5 hydroxytryptamine-glutaraldehyde-carrier
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, ddH20
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Serotonin / 5HT
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8882 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/100 - 1/5000.ELISA: 1/100 - 1/5000.
ICC
ICC: 1/2000 - 1/5000.ICC: 1/2000 - 1/5000.
IHC-Fr
IHC-Fr: 1/2000 - 1/5000.IHC-Fr: 1/2000 - 1/5000.
WB
WB: 1/1000 - 1/2000.WB: 1/1000 - 1/2000.
Target
Relevance
Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20µm) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors.
Cellular localization
Cytoplasmic and Secreted
Alternative names
- 5 HT antibody
- 5 hydroxytryptamine antibody
- 5HT antibody
References for Anti-Serotonin antibody (ab8882)
This product has been referenced in:
- Dai Yet al. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Psychopharmacology (Berl) 213:403-12 (2011). WB; Rat.Read more (PubMed: 20717650) »
- Bakst MR & Akuffo V Serotonin localization in the turkey vaginal but not sperm storage tubule epithelia. Poult Sci 87:356-61 (2008).Read more (PubMed: 18212381) »
See all 3 publications for this product
Publishing research using ab8882? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"