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Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Anti-Serum Amyloid A antibody [291]
See all Serum Amyloid A products (15) ...
Description
Mouse monoclonal [291] to Serum Amyloid A
Specificity
Reacts with recombinant human SAA. Does not cross-react with other human cytokines or growth factors tested such as IL1ß, IL8, MCAF, TGFß and EGF.
Tested applications
IP, ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein (Human).
Positive control
100ng/lane of recombinant protein
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 0.01M PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
291
Myeloma
Sp2/0-Ag14
Isotype
IgG2b
Light chain type
kappa
Research areas
Signal Transduction >> Metabolism >> Vitamins / Minerals
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Binding proteins
Cardiovascular >> Lipids / Lipoproteins >> Lipoproteins/Apolipoproteins >> Lipoproteins
Cardiovascular >> Blood >> Platelets
Cardiovascular >> Blood >> Serum Proteins
Cardiovascular >> Blood >> Acute Phase Reactants
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab18713 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent concentration.
ELISA: Use at an assay dependent dilution.
WB: Use a concentration of 0.1 - 0.5 µg/ml.Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa).
Target
Function
Major acute phase reactant. Apolipoprotein of the HDL complex.
Tissue specificity
Expressed by the liver; secreted in plasma.
Involvement in disease
Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Note=Elevated serum SSA protein levels may be associated with lung cancer.
Sequence similarities
Belongs to the SAA family.
Post-translational
modifications
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
Cellular localization
Secreted.
Target information above from: UniProt accessionP02735
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Amyloid fibril protein AA antibody
- Amyloid fibril protein AA antibody
- Amyloid protein A antibody
see all
Database links
- Entrez Gene: 6288 Human
- Entrez Gene: 6289 Human
- Omim: 104750 Human
- SwissProt: P02735 Human
- Unigene: 1955 Human
- Unigene: 632144 Human
References for Anti-Serum Amyloid A antibody [291] (ab18713)
This product has been referenced in:
- Wood SLet al. Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer. Br J Cancer 103:101-11 (2010). WB, IP; Human.Read more (PubMed: 20531413) »
- de Seny Det al. Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis. Clin Chem : (2008).Read more (PubMed: 18436720) »
See all 2 publications for this product
Publishing research using ab18713? Please let us know so that we can cite the reference in this datasheet
![Serum Amyloid A antibody [291] for Immunoprecipitation in Human (18713)](/ps/datasheet/images/18/ab18713/Serum-Amyloid-A-Primary-antibodies-ab18713-2.JPG)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"