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Product Name
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Serum Amyloid A antibody [291]
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See all Serum Amyloid A antibodies (15)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [291] to Serum Amyloid A
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Immunogen
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Recombinant full length protein (Human).
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Reacts with
(species key)
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Hu
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Specificity
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Reacts with recombinant human SAA. Does not cross-react with other human cytokines or growth factors tested such as IL1ß, IL8, MCAF, TGFß and EGF.
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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100ng/lane of recombinant protein
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Cellular localization
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Expressed by the liver; secreted in plasma.
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Research areas
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Signal Transduction >> Metabolism >> Vitamins / Minerals
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Binding proteins
Cardiovascular >> Lipids / Lipoproteins >> Lipoproteins/Apolipoproteins >> Lipoproteins
Cardiovascular >> Blood >> Platelets
Cardiovascular >> Blood >> Serum Proteins
Cardiovascular >> Blood >> Acute Phase Reactants
Immunology >> Innate Immunity >> Macrophage / Inflamm.
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Relevance
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The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP.
SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.
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Serum Amyloid A antibody [291] (ab18713) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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291
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Myeloma
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Sp2/0-Ag14
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Isotype
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IgG2b
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
Constituents: 0.01M PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Serum Amyloid A antibody [291] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for Serum Amyloid A antibody [291] (ab18713)
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This product has been used in:
de Seny D et al. Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis. Clin Chem : (2008). PubMed: 18436720
If you publish research using ab18713 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to Serum Amyloid A
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