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Product name
Simvastatin
Description
HMG-CoA reductase inhibitor
Biological description
HMG-CoA reductase inhibitor. Hypolipidemic, decreasing low denisty lipoprotein (LDL) levels. Implicated in a multitude of biological functions, demonstrating anti-cancer and anti-inflammatory properties.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2,2-dimethyl butanoate
Molecular Weight
418.57
Chemical structure
Molecular formula
C25H38O5
CAS Number
79902-63-9
Solubility
Soluble in DMSO to 50 mM and in ethanol to 50 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Stroke >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Obesity >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Hypertension >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Heart disease >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Diabetes >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Cancer >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Lipid signaling
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Lipid signaling
Biochemicals >> Pharmacology >> Signaling >> Lipid signaling >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> HMG-CoA reductase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Lipid signaling
Biochemicals >> Chemical Type >> Biochemicals
References for Simvastatin (ab120505)
This product has been referenced in:
- Kuchroo VK et al. T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function. Proc Natl Acad Sci U S A 88:8700-4 (1991).Read more (PubMed: 1833764) »
- Wacker H [The systematic viewpoint of family therapy. Possibilities and limitations in the everyday hospital stay]. Dtsch Krankenpflegez 43:262-6 (1990).Read more (PubMed: 2116273) »
See all 3 publications for this product
Publishing research using ab120505? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"